Although our bones seem solid and stable, they actually undergo constant renewal. Specialized cells called osteoclasts draw used calcium out of the bones while other cells called osteoblasts replace it. Especially after menopause, this process can get out of balance. Calcium starts to leach out of the bones faster than it can be replaced, leading to the brittle-bone disease called osteoporosis.
Actonel combats this problem by reducing the activity of the osteoclasts and slowing the loss of calcium from the bones. It is prescribed for postmenopausal women, both to prevent osteoporosis and to strengthen the bones once the disease has begun. It is also used to prevent or treat osteoporosis resulting from therapy with steroid medications, and it is used in the treatment of Paget’s disease, a condition in which patches of bone become softened and enlarged.
Both Actonel and a similar drug called Fosamax are members of the family of drugs called bisphosphonates.
Most important fact about Actonel
Actonel not only stops the bone loss of osteoporosis, but actually reverses the disease and increases bone mineral density. As the bones grow stronger, your chances of sustaining a fracture decline.
How should you take Actonel?
Three types of Actonel are available: a 5-milligram and 30-milligram tablet that can be taken daily, and a 35-milligram tablet that’s taken once a week. The tablets should be taken at least 30 minutes before the first food or drink of the day other than water. Take the pill while standing or sitting in an upright position and wash it down with a full 6 to 8 ounce glass of plain water (do not use coffee, tea, juice, milk, or other dairy products). Swallow the tablet whole, do not chew or suck on it. Do not lie down for 30 minutes after taking the medication.
Other treatment measures typically include weight-bearing exercise, reduction of excessive smoking and drinking, and supplemental calcium and vitamin D if you don’t get enough in your diet. If you require calcium supplements, or use any medications containing calcium, aluminum, or magnesium, avoid taking them at the same time of day as Actonel.
What side effects may occur?
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Actonel.
- More common side effects may include:
Abdominal pain, anxiety, back pain, belching, bladder irritation, bone disorders and pain, bronchitis, bursitis, cataracts, chest pain, colitis, constipation, depression, diarrhea, difficulty breathing, dizziness, dry eyes, eye infection, flu-like symptoms, gas, headache, high blood pressure, infection, insomnia, itching, joint disorders and pain, leg cramps, muscle pain, muscle weakness, nausea, neck pain, nerve pain, pain, pneumonia, rash, ringing in ears, sinus problems, sore throat, stomach bleeding, stuffy or runny nose, swelling, tendon problems, tumor, ulcers, urinary tract infection, vertigo, vision problems, weakness
Possible food and drug interactions when taking Actonel
If Actonel is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Actonel with the following:
Antacids
Calcium supplements
Laxatives such as Milk of Magnesia
Special information if you are pregnant or breastfeeding
Actonel has caused harm when tested on pregnant animals. It is not recommended during human pregnancy unless its benefits are judged to outweigh the potential risks. If you are pregnant or plan to become pregnant, notify your doctor immediately.
If you are nursing a baby, you’ll need to choose between discontinuing nursing or discontinuing the drug.
Recommended dosage
ADULTS
Osteoporosis
For the prevention and treatment of osteoporosis, the recommended dose is one 5-milligram tablet once daily or one 35-milligram tablet once a week.
Steroid-Induced Osteoporosis
For treatment or prevention of steroid-induced osteoporosis, the recommended dose is one 5-milligram tablet once a day.
Paget’s Disease
The recommended dose for Paget’s disease is 30 milligrams once a day for two months. A second 2-month course of therapy may be required in certain individuals.
Overdosage
A large overdose of Actonel can dramatically reduce calcium levels in the blood. Warning signs include a tingling sensation and spasms. If you suspect an overdose, seek medical attention immediately.
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If you miss a dose of VPXL, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
