Ketoconazole is an antifungal medication. It is like an antibiotic but is used to treat fungal infections.

Ketoconazole is used to treat yeast infections of the mouth, throat, and esophagus; fungal infections throughout the whole body; and serious fungal infections of the skin and nails.

Ketoconazole may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Nizoral (ketoconazole)?

Do not take ketoconazole if you are taking astemizole (Hismanal), cisapride (Propulsid), triazolam (Halcion), or midazolam (Versed). Combined with these drugs, ketoconazole could cause serious, even fatal, side effects.In rare cases, ketoconazole has caused severe liver damage, sometimes resulting in death. Notify your doctor immediately if you develop nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite, yellow skin or eyes, itching, dark urine, or clay colored stools. These symptoms may be early signs of liver damage.

Take all of the ketoconazole that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.

What should I discuss with my healthcare provider before taking Nizoral (ketoconazole)?

Do not take ketoconazole if you are taking any of the following drugs:

• astemizole (Hismanal),
• cisapride (Propulsid), or
• triazolam (Halcion) or midazolam (Versed).

Dangerous or life-threatening events may occur if ketoconazole is taken with any of the medicines listed above.

Before taking ketoconazole, tell your doctor if you have

• liver disease; or
• achlorhydria (decreased stomach acid production) or if you take antacids, stomach acid reducers, or stomach ulcer medicines.

You may not be able to take ketoconazole, or you may require a dosage adjustment, special monitoring, or special directions for use during your treatment.

Ketoconazole is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. Ketoconazole passes into breast milk and may be harmful to a nursing baby. For this reason, ketoconazole should not be taken by nursing mothers. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take Nizoral (ketoconazole)?

Take ketoconazole exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.Ketoconazole is usually taken once a day. Follow your doctor’s instructions.

If you have a condition that decreases the amount of acid produced by the stomach, you may require a special mixture of this medication. Drink this solution through a straw far back in the mouth away from the teeth and follow each dose with a swish and swallow of water to prevent damage to the teeth.

It is important to take ketoconazole regularly to get the most benefit.

Your doctor may want you to have blood tests or other medical evaluations during treatment with ketoconazole to monitor progress and side effects.

Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected.Symptoms of a ketoconazole overdose are not well known but might include dizziness, ringing in the ears, headache, nausea, vomiting, diarrhea, and abdominal pain.

Nizoral (ketoconazole) side effects

If you experience any of the following serious side effects, stop taking ketoconazole and seek emergency medical attention or contact your doctor immediately:

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or
• liver damage (pale stools, yellowish skin or eyes, abdominal pain, unusual fatigue, or dark urine).

Other, less serious side effects may be more likely to occur. If you experience any of the following side effects, continue to take ketoconazole and talk to your doctor:

• nausea, vomiting, or abdominal pain;
• diarrhea;
• headache;
• dizziness;
• fatigue; or
• itching.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Nizoral (ketoconazole)?

Do not take ketoconazole if you are taking any of the following drugs:

• astemizole (Hismanal),
• cisapride (Propulsid), or
• triazolam (Halcion) or midazolam (Versed).

Dangerous or life-threatening events may occur if ketoconazole is taken with any of the medicines listed above.

Before taking ketoconazole, tell your doctor if you are taking any other medicines, especially any of the following:

• cyclosporine (Sandimmune, Neoral);
• tacrolimus ((Prograf);
• methylprednisolone (Medrol, others);
• antacids;
• cimetidine (Tagamet, Tagamet HB), nizatidine (Axid, Axid AR), famotidine (Pepcid, Pepcid AC), or ranitidine (Zantac, Zantac 75);
• omeprazole (Prilosec), lansoprazole (Prevacid), or rabeprazole (Aciphex);
• digoxin (Lanoxin, Lanoxicaps);
• warfarin (Coumadin);
• phenytoin (Dilantin, others);
• rifampin (Rifadin, Rimactane); or
• an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), tolbutamide (Orinase), tolazamide (Tolinase), chlorpropamide (Diabinese), and others.

You may not be able to take ketoconazole, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with ketoconazole or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Nizoral

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Clotrimazole is an antifungal medication. It prevents fungus from growing.

Clotrimazole vaginal is used to treat vaginal candida (yeast) infections.

Clotrimazole vaginal may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Mycelex-G (clotrimazole vaginal)?

Use this medication for the full amount of time prescribed by your doctor or recommended in the package even if you begin to feel better. Your symptoms may improve before the infection is completely healed.Avoid wearing tight-fitting, synthetic clothing (e.g., panty hose) that does not allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed.

Avoid getting this medication in your eyes, nose, or mouth.

How should I use Mycelex-G (clotrimazole vaginal)?

Use clotrimazole vaginal exactly as directed by your doctor, or follow the directions that accompany the package. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.Wash your hands before and after using this medication.

Insert the tablet, suppository, or cream into the vagina using the applicator as directed.Use this medication continuously for the prescribed amount of time, even during your menstrual period.

You can use a sanitary napkin to prevent the medication from staining your clothing but do not use a tampon.

If the infection does not clear up after you have finished one course of therapy, or if it appears to get worse, see your doctor. You may have another type of infection.

Avoid getting this medication in your eyes, nose, or mouth. Store clotrimazole vaginal at room temperature away from moisture and heat.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and apply only your next regularly scheduled dose. Do not use a double dose of this medication.

What happens if I overdose?

An overdose of clotrimazole vaginal is unlikely to occur. If you do suspect that a much larger than normal dose has been used or that clotrimazole vaginal has been ingested, contact an emergency room or a poison control center.

Mycelex-G (clotrimazole vaginal) side effects

Stop using clotrimazole vaginal and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).Other, less serious side effects may be more likely to occur. These include burning, itching, irritation of the skin, and an increased need to urinate.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Mycelex-G (clotrimazole vaginal)?

Avoid using other vaginal creams or douches at the same time as clotrimazole unless your doctor approves.

Drugs other than those listed here may also interact with clotrimazole vaginal. Talk to your doctor and pharmacist before taking any prescription or over the counter medicines.

Mycelex-G

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