Progesterone is a female hormone important for the regulation of ovulation and menstruation.

Progesterone is used to cause menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body. Progesterone is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy.

Progesterone may also be used for purposes other than those listed in this medication guide.

How should I take Prometrium (Progesterone)?

Use this medication exactly as it was prescribed for you. Do not use larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label.

Progesterone is sometimes given for only a short period of time, such as 6 to 12 days at a time during each menstrual cycle. Following your dosing schedule is very important for this medication to be effective. Try not to miss any doses.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Take the pill form of progesterone with a full glass of water.

Apply progesterone cream to the skin as directed by your doctor.

Progesterone injection is given as a shot into a muscle. Your doctor, nurse, or other healthcare provider will give you this injection. You may be given instructions on how to use your injections at home. Do not use this medicine at home if you do not fully understand how to give the injection and properly dispose of needles and syringes used in giving the medicine.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using progesterone.

Your doctor will need to see you on a regular basis while you are using this medication. Do not miss any appointments.

Store progesterone at room temperature away from moisture, heat, and light.

What are the possible side effects of Prometrium (Progesterone)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

• sudden numbness or weakness, especially on one side of the body
• sudden headache, confusion, pain behind the eyes, problems with vision, speech, or balance
• chest pain, pounding heartbeats
• migraine headache
• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
• swelling in your hands, ankles, or feet
• fever, chills, body aches, flu symptoms
• a breast lump; or
• symptoms of depression (sleep problems, weakness, mood changes)

Continue using the medication and talk to your doctor if you have any of these less serious side effects:

• mild nausea, diarrhea, bloating, stomach cramps
• dizziness
• mild headache
• muscle pain
• breast pain or tenderness
• cough
• acne or increased hair growth
• changes in weight
• vaginal itching, dryness, or discharge; or
• feeling irritable

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs affect Prometrium (Progesterone)?

There may be other drugs that can affect progesterone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What should I avoid while taking Prometrium (Progesterone)?

Progesterone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

What happens if I overdose on Prometrium (Progesterone)?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a progesterone overdose are not known.

What happens if I miss a dose of Prometrium (Progesterone)?

Use the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

Call your doctor if you miss more than one dose of this medication.

What is the most important information I should know about Prometrium (Progesterone)?

Do not use this medication without telling your doctor if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Some forms of this medication may contain peanut oil. Do not use progesterone without telling your doctor if you have a peanut allergy.

Using progesterone can increase your risk of blood clots, stroke, heart attack, or breast cancer.

Do not use this medication if you have any of the following conditions: a history of stroke or blood clot, circulation problems, severe liver disease, a hormone-related cancer such as breast or uterine cancer, abnormal vaginal bleeding, or if you have recently had an incomplete or “missed” abortion.

Progesterone is sometimes given for only a short period of time, such as 6 to 12 days at a time during each menstrual cycle. Following your dosing schedule is very important for this medication to be effective. Try not to miss any doses.

Progesterone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

What should I discuss with my healthcare provider before taking Prometrium (Progesterone)?

Some forms of this medication may contain peanut oil. Do not use progesterone without telling your doctor if you have a peanut allergy.

Do not use progesterone if you have:

• a history of stroke or blood clot
• circulation problems
• a hormone-related cancer such as breast or uterine cancer
• abnormal vaginal bleeding
• severe liver disease
• if you are pregnant; or
• if you have recently had an incomplete or “missed” abortion

Before using this medication, tell your doctor if you have any of the following conditions. You may not be able to use progesterone, or you may need a dosage adjustment or special tests during treatment.

• high blood pressure, heart disease, congestive heart failure
• migraines,
• asthma
• kidney disease
• seizures or epilepsy
• a history of depression; or
• diabetes

Do not use progesterone without your doctor’s consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication.

Progesterone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

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Zyban is used for Helping certain patients to stop smoking cigarettes. It may also be used for other conditions as determined by your doctor.

Zyban Sustained-Release Tablets is an antidepressant that has been found to aid in the stopping of smoking.

Do NOT use Zyban Sustained-Release Tablets if:

• you are allergic to any ingredient in Zyban Sustained-Release Tablets
• you are taking any other medicine that contains bupropion
• you have a history of an eating disorder (eg, anorexia, bulimia) or seizures (eg, epilepsy)
• you are suddenly stopping the use of alcohol or sedatives (eg, benzodiazepines) after long-term use
• you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zyban Sustained-Release Tablets:

Some medical conditions may interact with Zyban Sustained-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you or a family member has a history of bipolar disorder (manic depression), other mental or mood problems (eg, depression), suicidal thoughts or attempts, or alcohol or substance abuse
• if you have diabetes, kidney problems, high blood pressure, heart problems (eg, congestive heart failure), or a recent heart attack
• if you have a history of seizure, head injury, tumor in the brain or spinal cord, or liver problems (eg, cirrhosis)

Some MEDICINES MAY INTERACT with Zyban Sustained-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Amantadine, antipsychotics (eg, haloperidol, risperidone), corticosteroids (eg, prednisone), insulin, levodopa, MAOIs (eg, phenelzine), nicotine patches, oral hypoglycemics (eg, glipizide), other antidepressants (eg, fluoxetine, amitriptyline), sympathomimetics (eg, pseudoephedrine), theophylline, or tiagabine because they may increase the risk of Zyban Sustained-Release Tablets’s side effects
• Carbamazepine, phenobarbital, or phenytoin because they may decrease Zyban Sustained-Release Tablets’s effectiveness
• Antiarrhythmics (eg, propafenone, flecainide), beta-blockers (eg, metoprolol), phenothiazines (eg, thioridazine), selective serotonin reuptake inhibitor (SSRI) antidepressants (eg, fluoxetine), or tricyclic antidepressants (eg, nortriptyline) because the risk of their side effects may be increased by Zyban Sustained-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zyban Sustained-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zyban Sustained-Release Tablets:

Use Zyban Sustained-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Zyban Sustained-Release Tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Zyban Sustained-Release Tablets refilled.
• Take Zyban Sustained-Release Tablets by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Swallow Zyban Sustained-Release Tablets whole. Do not break, crush, or chew before swallowing.
• Several weeks may pass before your symptoms improve. Do not stop taking Zyban Sustained-Release Tablets without checking with your doctor.
• Take your doses at the same times each day at least 8 hours apart unless directed otherwise by your doctor. This may help to decrease the risk of seizures with Zyban Sustained-Release Tablets.
• It takes about 1 week for Zyban Sustained-Release Tablets to work. You should begin taking Zyban Sustained-Release Tablets while you are still smoking. However, you and your doctor should decide on a date that you will stop smoking during the 2nd week of taking Zyban Sustained-Release Tablets.
• If you have not made progress towards stopping smoking by the 12th week, contact your doctor.
• If you are not able to stop smoking while using Zyban Sustained-Release Tablets, talk to your doctor to determine why you were not successful. After the reasons have been reduced or eliminated, you should try to stop smoking again.
• Continue to take Zyban Sustained-Release Tablets even if you feel well. Do not miss any doses.
• If you miss a dose of Zyban Sustained-Release Tablets, skip the missed dose. Go back to your regular dosing schedule. Do not take more than 1 dose within 8 hours. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zyban Sustained-Release Tablets.

Important safety information:

• Zyban may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Zyban Sustained-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking Zyban Sustained-Release Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Zyban Sustained-Release Tablets may increase your risk of seizures. Your risk may be greater if you also have certain medical conditions, use certain medicines, or if you drink large amounts of alcohol. Talk to your doctor to see if you may have a greater risk of seizures while taking Zyban Sustained-Release Tablets.
• If you already drink alcohol or use sedatives, do not suddenly stop them without first checking with your doctor. Suddenly stopping them may increase your seizure risk.
• Do not take decongestants (eg, pseudoephedrine), stimulants, or diet pills while you are taking Zyban Sustained-Release Tablets without first checking with your doctor. They may increase your risk of seizures.
• The risk of seizures may be greater if you take Zyban Sustained-Release Tablets in high doses or for a long time. Do NOT take more than the recommended dose, change your dose, or use Zyban Sustained-Release Tablets for longer than prescribed without checking with your doctor.
• Children, teenagers, and young adults who take Zyban Sustained-Release Tablets may be at increased risk for suicidal thoughts or actions. Watch all patients who take Zyban Sustained-Release Tablets closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
• If you have trouble sleeping, you may be taking your dose too close to bedtime. Talk with your doctor about changing your dosing schedule.
• It is important to follow the program that your doctor has prescribed, including behavioral changes, counseling, or support services, in order to stop smoking.
• Zyban Sustained-Release Tablets can be used together with the nicotine skin patches only under the supervision of your doctor. Using these medicines together may raise your blood pressure. If you are already using a nicotine skin patch, your blood pressure should be checked regularly.
• Do not smoke if you are using Zyban Sustained-Release Tablets along with the nicotine skin patch or any nicotine product.
• Stopping smoking may change the amount of certain medicines (eg, theophylline, warfarin) in your blood. Be sure your doctor knows all the medicines that you are taking.
• Zyban Sustained-Release Tablets contains the same ingredients as Wellbutrin, an antidepressant. Do not take Zyban Sustained-Release Tablets if you are also taking Wellbutrin or other brands of bupropion. Discuss any questions or concerns with your doctor.
• Use Zyban Sustained-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects.
• Zyban Sustained-Release Tablets should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zyban Sustained-Release Tablets while you are pregnant. Zyban Sustained-Release Tablets is found in breast milk. Do not breast-feed while taking Zyban Sustained-Release Tablets.

Possible side effects of Zyban:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; diarrhea; dizziness; drowsiness; dry mouth; loss of appetite; nausea; nervousness; stomach pain; stuffy nose; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; chest pain; concentration problems, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated sense of well-being, inability to sit still, or other unusual or severe mental or mood changes; confusion; changes in sexual desire or ability; delusions; fainting; fast or irregular heartbeat; fever or chills; hallucinations; hearing problems or ringing in the ears; joint or muscle pain; menstrual changes; red, swollen, blistered, or peeling skin; seizures; severe headache or dizziness; severe or persistent anxiety, agitation, restlessness, or trouble sleeping; shortness of breath; suicidal thoughts or attempts; tremor.

Zyban

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