
Progesterone is a female hormone important for the regulation of ovulation and menstruation.
Progesterone is used to cause menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body. Progesterone is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy.
Progesterone may also be used for purposes other than those listed in this medication guide.
How should I take Prometrium (Progesterone)?
Use this medication exactly as it was prescribed for you. Do not use larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label.
Progesterone is sometimes given for only a short period of time, such as 6 to 12 days at a time during each menstrual cycle. Following your dosing schedule is very important for this medication to be effective. Try not to miss any doses.
This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
Take the pill form of progesterone with a full glass of water.
Apply progesterone cream to the skin as directed by your doctor.
Progesterone injection is given as a shot into a muscle. Your doctor, nurse, or other healthcare provider will give you this injection. You may be given instructions on how to use your injections at home. Do not use this medicine at home if you do not fully understand how to give the injection and properly dispose of needles and syringes used in giving the medicine.
This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using progesterone.
Your doctor will need to see you on a regular basis while you are using this medication. Do not miss any appointments.
Store progesterone at room temperature away from moisture, heat, and light.
What are the possible side effects of Prometrium (Progesterone)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:
- sudden numbness or weakness, especially on one side of the body
- sudden headache, confusion, pain behind the eyes, problems with vision, speech, or balance
- chest pain, pounding heartbeats
- migraine headache
- nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
- swelling in your hands, ankles, or feet
- fever, chills, body aches, flu symptoms
- a breast lump; or
- symptoms of depression (sleep problems, weakness, mood changes)
Continue using the medication and talk to your doctor if you have any of these less serious side effects:
- mild nausea, diarrhea, bloating, stomach cramps
- dizziness
- mild headache
- muscle pain
- breast pain or tenderness
- cough
- acne or increased hair growth
- changes in weight
- vaginal itching, dryness, or discharge; or
- feeling irritable
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
What other drugs affect Prometrium (Progesterone)?
There may be other drugs that can affect progesterone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
What should I avoid while taking Prometrium (Progesterone)?
Progesterone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
What happens if I overdose on Prometrium (Progesterone)?
Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a progesterone overdose are not known.
What happens if I miss a dose of Prometrium (Progesterone)?
Use the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.
Call your doctor if you miss more than one dose of this medication.
What is the most important information I should know about Prometrium (Progesterone)?
Do not use this medication without telling your doctor if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.
Some forms of this medication may contain peanut oil. Do not use progesterone without telling your doctor if you have a peanut allergy.
Using progesterone can increase your risk of blood clots, stroke, heart attack, or breast cancer.
Do not use this medication if you have any of the following conditions: a history of stroke or blood clot, circulation problems, severe liver disease, a hormone-related cancer such as breast or uterine cancer, abnormal vaginal bleeding, or if you have recently had an incomplete or “missed” abortion.
Progesterone is sometimes given for only a short period of time, such as 6 to 12 days at a time during each menstrual cycle. Following your dosing schedule is very important for this medication to be effective. Try not to miss any doses.
Progesterone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
What should I discuss with my healthcare provider before taking Prometrium (Progesterone)?
Some forms of this medication may contain peanut oil. Do not use progesterone without telling your doctor if you have a peanut allergy.
Do not use progesterone if you have:
- a history of stroke or blood clot
- circulation problems
- a hormone-related cancer such as breast or uterine cancer
- abnormal vaginal bleeding
- severe liver disease
- if you are pregnant; or
- if you have recently had an incomplete or “missed” abortion
Before using this medication, tell your doctor if you have any of the following conditions. You may not be able to use progesterone, or you may need a dosage adjustment or special tests during treatment.
- high blood pressure, heart disease, congestive heart failure
- migraines,
- asthma
- kidney disease
- seizures or epilepsy
- a history of depression; or
- diabetes
Do not use progesterone without your doctor’s consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication.
Progesterone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
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