Lynoral is used for preventing pregnancy. It may be used for other conditions as determined by your doctor. Lynoral is a synthetic estrogen that is used to treat symptoms of menopause, certain types of breast cancer, and prostate cancer.

How Taken

Take ethinyl estradiol and norethindrone exactly as directed by your doctor.

Drug Class and Mechanism

Ethinyl estradiol is a progesterone and estrogen combination birth control pill. It works by preventing ovulation, thickening the mucus in the cervix, and changing the lining of the uterus.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, take the missed dose and resume your usual dosing schedule; this may mean taking two tablets in one day. If you miss two or more doses in a row, use an alternate birth control method (e.g., condoms, spermicides) for at least 7 days and consult the product information or your doctor for a new dosing schedule.

Storage

Store at room temperature between 59 and 86 degrees F (15 and 30 degrees C) away from light and moisture.

Warnings Precautions

Smoking cigarettes while using this medication increases your chance of having heart problems. Do not smoke while using this medication. The risk of heart problems increases with age (in women greater than 35 years of age) and with frequent smoking (15 cigarettes per day or greater).

Possible Side Effects

Nausea, vomiting, headache, diarrhea, bleeding between menstrual periods (spotting), weight gain, acne, stomach cramps, rash, swelling or bloating, skin spots, breast tenderness, or difficulty wearing contact lenses may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these serious side effects occur: dizziness, flu-like symptoms (e.g., fever, cough, unusual weakness/fatigue, sore throat, muscle aches), mental/mood changes, trouble sleeping, hair loss, vaginal infections. Tell your doctor immediately if any of these unlikely but serious side effects occur: severe headache, pain in the lower legs or groin, trouble breathing, chest pain, vision changes, severe stomach pain, one-sided weakness, yellowing eyes or skin, lumps in the breast. If you notice any other effects not listed above, contact your doctor or pharmacist.

More Information

Do not share this medication with others. Keep all appointments with your doctor and the laboratory. Laboratory tests (e.g., potassium levels) may be performed to monitor for possible side effects to this medication. You should have a complete physical examination that includes blood pressure measurements and breast/pelvic examinations at regular intervals (e.g., once a year) or as directed by your doctor. Follow your doctor’s instructions on how to examine your own breasts and report any lumps immediately. You should also be regularly screened for cervical cancer (e.g., Pap test).

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Letrozole blocks the use of estrogen by certain types of breast cancer that require estrogen to grow.

Letrozole is used with other medicines to treat breast cancer in women who have reached menopause.

Letrozole may also be used for purposes other than those listed here.

How should I take Femara (Letrozole)?

Take letrozole exactly as it was prescribed for you. Do not take it in larger doses or for longer than recommended by your doctor.

Take each dose with a full glass (8 ounces) of water.

Letrozole is usually taken once a day. Follow your doctor’s instructions.

Letrozole can be taken with or without food.

To be sure this medication is helping your condition, you will need to be tested on a regular basis. Your bone mineral density may also need to be checked. It is important that you not miss any scheduled visits to your doctor.

Store letrozole at room temperature away from moisture and heat.

What are the possible side effects of Femara (Letrozole)?

Stop using letrozole and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Other less serious side effects are more likely to occur, such as:

• hot flashes, warmth or redness in your face or chest
• headache, muscle or joint pain
• night sweats
• weight gain
• fatigue, feeling weak
• nausea; or
• swelling in your hands, ankles, or feet

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs affect Femara (Letrozole)?

There may be other drugs not listed that can affect letrozole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What should I avoid while taking Femara (Letrozole)?

Letrozole can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

What happens if I overdose on Femara (Letrozole)?

Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of letrozole is not expected to produce life-threatening symptoms.

What happens if I miss a dose of Femara (Letrozole)?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What is the most important information I should know about Femara (Letrozole)?

Before taking letrozole, tell your doctor if you have liver disease.You may not be able to use letrozole or you may need a dosage adjustment or special tests during treatment.

Do not use this medication if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Use this medication exactly as it was prescribed for you. Do not use it in larger doses or for longer than recommended by your doctor.

There may be other drugs that can affect letrozole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Stop using this medication and get emergency medical help if you think you have used too much medicine, or if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects are more likely, and you may have none at all. Talk to your doctor about any side effect that seems unusual or is especially bothersome.

What should I discuss with my healthcare provider before taking Femara (Letrozole)?

Before taking letrozole, tell your doctor if you have liver disease. You may not be able to use letrozole or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category D: This medication can cause harm to an unborn baby. Do not use letrozole if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication.

It is not known whether letrozole passes into breast milk. Do not take letrozole if you are breast-feeding a baby.

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Treating endometriosis, symptoms of fibrocystic breast disease, orgiant hives. It may also be used for other conditions as determined by your doctor.

Danazol is a synthetic steroid. It works by decreasing the level of certain hormones, which reduces the symptoms and severity of the diseases treated by Danazol .

Do NOT use Danazol if:

• you are allergic to any ingredient in Danazol
• you are pregnant or breast-feeding
• you have undiagnosed vaginal bleeding
• you have the blood disease porphyria or severely decreased liver, kidney, or heart function

Contact your doctor or health care provider right away if any of these apply to you.

Do not use Danazol if you are pregnant. It is recommended that a pregnancy test be performed before starting Danazol . Effective, nonhormonal contraceptive (birth control) measures, such as diaphragms and condoms, should be used while taking Danazol . Danazol may cause serious harm to a fetus. If you become pregnant while taking Danazol , stop use and contact your health care provider. Life-threatening strokes and increased pressure in the head have occurred from using Danazol . Notify your doctor immediately if you develop any of the following: one-sided weakness, sudden vision changes, slurred speech, arm or leg pain, breathing trouble, chest pain, yellowing eyes/skin, dark urine, dizziness, fainting, swelling, stomach pain, head pain.

Before using Danazol :

Some medical conditions may interact with Danazol . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of blood clots or stroke, cancer, heart failure, heart disease, or liver or kidney problems

Some MEDICINES MAY INTERACT with Danazol . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), carbamazepine, cyclosporine, or macrolide immunosuppressants (eg, tacrolimus) because the actions and side effects of these medicines may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Danazol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Danazol :

Use Danazol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Danazol may be taken with or without food.
• If you are being treated for endometriosis or fibrocystic breast disease, you should begin treatment during menstruation.
• Endometriosis patients – You must take Danazol consistently for 3 to 6 months. It may be necessary to take Danazol for 9 months.
• If you miss a dose of Danazol , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Danazol .

Possible side effects of Danazol :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Acne; changes in menstrual flow; changes in semen volume and sperm count; emotional problems; excessively oily skin; flushing; hair loss; nervousness; reduction in breast size; sweating; vaginal itching or dryness; voice changes (hoarseness, sore throat, change in pitch); weight gain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal hair growth; arm or leg pain; breathing trouble; chest pain; dark urine; dizziness; fainting; headache; nausea; one-sided weakness; slurred speech; sore throat or fever; stomach pain; swelling; unusual bleeding or bruising; vision problems; vomiting; yellowing of the skin or eyes.

Important safety information:

• Danazol may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Danazol . Using Danazol alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Do not take more medicine than prescribed unless advised to do so by your doctor.
• It may take several months for Danazol to work. Do not stop using Danazol without checking with your doctor.
• Use a barrier contraceptive (birth control), such as a condom or diaphragm, while taking Danazol .
• Diabetes patients – Danazol may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
• LAB TESTS, including liver function tests and complete blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• Use Danazol with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Do not use Danazol if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. Danazol is excreted in breast milk. Do not breast-feed while taking Danazol .

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