Pyridium is a urinary tract analgesic that helps relieve the pain, burning, urgency, frequency, and irritation caused by infection, trauma, catheters, or various surgical procedures in the lower urinary tract. Pyridium is indicated for short-term use and can only relieve symptoms; it is not a treatment for the underlying cause of the symptoms.

Most important fact about Pyridium

Pyridium produces an orange to red color in urine, and may stain fabric. Staining of contact lenses has also been reported.

How should you take Pyridium?

Take Pyridium after meals, exactly as prescribed.

• If you miss a dose…
  Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

• Storage instructions…
  Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any occur or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Pyridium.

• Side effects may include:
  Headache, itching, rash, severe allergic reaction (rash, difficulty breathing, fever, rapid heartbeat, convulsions), upset stomach

Special information if you are pregnant or breastfeeding

The effects of Pyridium during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. To date, there is no information on whether Pyridium appears in breast milk. If this medication is essential to your health, your doctor may advise you to stop breastfeeding until your treatment with Pyridium is finished.

Recommended dosage for Pyridium

ADULTS

The usual dose is two 100-milligram tablets or one 200-milligram tablet 3 times a day after meals.

You should not take Pyridium for more than 2 days if you are also taking an antibiotic for the treatment of a urinary tract infection.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek emergency medical treatment immediately.

• Symptoms of Pyridium overdose may include:
  Blood disorders, bluish skin color, impaired kidney and liver function

Pyridium

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Along with rest and physical therapy, Skelaxin is prescribed for the relief of painful musculoskeletal conditions. Researchers aren’t sure how the drug works, but suspect that its effectiveness stems from its sedative properties.

Skelaxin should be avoided by anyone with significant liver or kidney problems.

How should you take Skelaxin?

No special instructions apply. Take exactly as prescribed.

–If you miss a dose…

Take the forgotten dose as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular schedule. Do not take two doses at once.

–Storage instructions…

Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe to continue using Skelaxin.

• More common side effects may include:
  Dizziness, drowsiness, headache, irritability, nausea, nervousness, stomach upset, vomiting

Special information if you are pregnant or breastfeeding

It’s best to avoid using Skelaxin during pregnancy–particularly early pregnancy–unless the potential benefits clearly outweigh the possible risks. If you are pregnant or plan to become pregnant, notify your doctor immediately.

It is not known whether Skelaxin makes its way into breast milk. Breastfeeding while using the drug is not recommended.

Recommended dosage

ADULTS

The usual dose for adults and children over 12 is 800 milligrams (2 tablets) 3 or 4 times a day.

Overdosage

There have been no reports of major Skelaxin overdose. However, any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

• Possible symptoms of Skelaxin overdose may include:
  Sedation, depressed breathing

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Adding Omega fats (Salmon Oil, Flaxseed Oil and Borage Seed Oil) to dieting can reverse, prevent, or alleviate health concerns.

How Taken

For adults, take two (2) softgels daily preferably with a meal.

Drug Class and Mechanism

Omega 3-1fats include DHA docoahexaenoic acid is high enough amounts will support retinal health and brain function. EPA eicosapentoic acid aids in the reduction of inflammation as in Arthritis.

Omega 3-1fats are important for the production of prostaglandins a hormone like substance that is needed for such things as control of smooth muscle contraction. It also helps to lower blood pressure and body temperature as well as reducing inflammation. Other physiological functions that are regulated by prostaglandins are blood clotting, nerve transmission, kidney function and inflammatory and allergic responses. The production of other hormones is also aided by prostaglandins.

A diet rich in Omega 3-1helps cell membranes to function properly. Other health issues such as cancer, heart disease, asthma, rheumatoid arthritis, obesity, diabetes, and ADD/ADHD can be positively affected by consuming Omega 3-1fats. Brain and retinal health is supported by Omega 3’s. DHA in high amounts will benefit brain function. Alzheimer’s, Macular Degeneration and memory are also improved with adequate amounts of Omega 3 fats either in your diet or in supplement form.

Missed Dose

If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

Storage

Store Omega 3-1 at 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not store in the bathroom. Keep Omega 3-1 out of the reach of children and away from pets.

Warnings Precautions

No absolute contraindications. Consult your healthcare professional if pregnant or nursing.

Possible Side Effects

Omega 3-1 is not known to have any side effects if taken as per the prescribed dosage.

More Information

Recent research highlights the importance of getting Omega fatty acids. Fatty acids - Omega-3, Omega-6 and Omega-9 are the good fats important for cellular, heart and metabolic health. Many of these fatty acids are essential - meaning your body needs them but cannot make them so they must be obtained from diet. Omega 3-1 contains essential and nonessential fatty acids found in Salmon Oil, Flaxseed Oil and Borage Seed Oil.

Omega 3-1

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Anacin is a combination salicylate and stimulant. It works by blocking several different chemical processes within the body that cause pain, inflammation, and fever. It also reduces the tendency for blood to clot.

Do NOT use Anacin if:

• you are allergic to any ingredient in Anacin
• you are a child or teenager with influenza (flu) or chickenpox
• you have bleeding problems such as hemophilia, von Willebrand disease, or low blood platelets, or you have active severe bleeding
• you have had a severe allergic reaction (eg, severe rash, hives, breathing difficulties, dizziness) to aspirin, tartrazine, or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen, celecoxib)
• you are taking anticoagulants (eg, heparin, warfarin) or methotrexate

Contact your doctor or health care provider right away if any of these apply to you.

Before using Anacin :

Some medical conditions may interact with Anacin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have alcoholism or if you consume 3 or more alcohol-containing drinks every day
• if you have asthma, bleeding or clotting problems, growths in the nose (nasal polyps), kidney or liver problems, stomach or intestinal problems (eg, ulcer, inflammation), heart problems, heartburn, upset stomach, stomach pain, hives, influenza (flu) or chickenpox, or vitamin K deficiency
• if you have anxiety, trouble sleeping, or heart problems
• if you are a child with a stroke, a weakened blood vessel (cerebral aneurysm) or bleeding in the brain, rheumatic disease (eg, rheumatoid arthritis), or Kawasaki syndrome (a rare inflammation causing heart problems in children)

Some MEDICINES MAY INTERACT with Anacin . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Carbonic anhydrase inhibitors (eg, acetazolamide) because they may decrease Anacin ’s effectiveness
• Anticoagulants (eg, heparin, warfarin), clopidogrel, or NSAIDs (eg, ibuprofen, celecoxib) because the risk of their side effects, including risk of bleeding, may be increased by Anacin
• Quinolones (eg, ciprofloxacin) because side effects, such as problems sleeping, nervousness, jitteriness, or anxiety, may occur
• Insulin or oral antidiabetics (eg, glyburide, nateglinide) because the risk of their side effects, including low blood sugar (eg, hunger, shakiness or weakness, dizziness, headache, sweating), may be increased by Anacin
• Methotrexate, theophylline, or valproic acid because the risk of their actions and side effects may be increased by Anacin
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), probenecid, or sulfinpyrazone because their effectiveness may be decreased by Anacin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Anacin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Anacin :

Use Anacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Anacin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Taking it with food may not decrease the risk of stomach or bowel problems (eg, bleeding, ulcers) that may occur while taking Anacin .
• Take Anacin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Anacin .
• Use Anacin exactly as directed on the package, unless instructed differently by your doctor. If you are taking Anacin without a prescription, follow any warnings and precautions on the label.
• If you miss a dose of Anacin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Anacin .

Important safety information:

• Anacin may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Anacin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate). This includes any medicines that contain caffeine.
• Anacin has aspirin in it. Before you start any new medicine, check the label to see if it has aspirin in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Talk to your doctor before you take Anacin or other pain relievers/fever reducers if you drink more than 3 drinks with alcohol per day. Serious stomach ulcers or bleeding can occur with the use of Anacin . Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Anacin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Taking more than the recommended dose or taking Anacin regularly may be habit-forming.
• Anacin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
• Aspirin has been linked to a serious illness called Reye syndrome. Do not give Anacin to a child or teenager who has the flu, chickenpox, or a viral infection. Contact your doctor with any questions or concerns.
• Diabetes patients - Anacin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• If Anacin has a strong vinegar-like smell upon opening, do not use. It means the medicine is breaking down. Throw the bottle away safely and out of the reach of children; contact your pharmacist and replace.
• Tell your doctor or dentist that you take Anacin before you receive any medical or dental care, emergency care, or surgery.
• Do not take Anacin for at least 7 days after any surgery unless directed by your health care provider.
• Do not take Anacin for more than 10 days for pain or for more than 3 days for fever unless directed to do so by your health care provider.
• Different brands of Anacin may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Anacin while you are pregnant. Anacin is not recommended during the last 3 months (third trimester) of pregnancy because it may cause harm to the fetus. This medicine is found in breast milk. If you are or will be breast-feeding while you use Anacin , check with your doctor. Discuss any possible risks to your baby.

Some people who use Anacin for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.

If you stop taking Anacin suddenly, you may have WITHDRAWAL symptoms including dizziness, headache, unusual tiredness, irritability, muscle tension, and nausea.

Possible side effects of Anacin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; heartburn; irritability; nausea; nervousness; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; confusion; diarrhea; drowsiness; hearing loss; ringing in the ears; severe or persistent dizziness; severe or persistent stomach pain or heartburn; shakiness; trouble sleeping; vomiting.

Anacin

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Diclofenac is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac works by reducing hormones that cause inflammation and pain in the body.

Diclofenac is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis.

Diclofenac may also be used for purposes other than those listed in this medication guide.

How should I take Voltaren (Diclofenac)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

If you switch brands of diclofenac, your dose needs may change. Follow your doctor’s instructions about how much medicine to take.

Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.

If you take diclofenac for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.

Store diclofenac at room temperature away from moisture and heat.

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Diclofenac is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac works by reducing hormones that cause inflammation and pain in the body.

Diclofenac is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis.

Diclofenac may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking diclofenac?

Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Do not use this medication if you are allergic to diclofenac, or if you have a history of allergic reaction to aspirin or other NSAIDs.

Before taking diclofenac, tell your doctor if you are allergic to any drugs, or if you have:

• a history of heart attack, stroke, or blood clot;
• heart disease, congestive heart failure, high blood pressure;
• a history of stomach ulcers or bleeding;
• liver or kidney disease,
• asthma;
• polyps in your nose;
• a bleeding or blood clotting disorder; or
• if you smoke.

If you have any of these conditions, you may not be able to use diclofenac, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking diclofenac during the last 3 months of pregnancy may result in birth defects. Do not take diclofenac during pregnancy unless your doctor has told you to. Diclofenac can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to a child without the advice of a doctor.

How should I take diclofenac?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

If you switch brands of diclofenac, your dose needs may change. Follow your doctors instructions about how much medicine to take.

Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.

If you take diclofenac for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.

Store diclofenac at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a diclofenac overdose may include nausea, vomiting, stomach pain, drowsiness, black or bloody stools, coughing up blood, shallow breathing, fainting, or coma.

What are the possible side effects of diclofenac?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking diclofenac and seek medical attention or call your doctor at once if you have any of these serious side effects:

• chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
• black, bloody, or tarry stools;
• coughing up blood or vomit that looks like coffee grounds;
• swelling or rapid weight gain;
• urinating less than usual or not at all;
• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
• bruising, severe tingling, numbness, pain, muscle weakness; or
• fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions).

Keep taking diclofenac and talk to your doctor if you have any of these less serious side effects:

• upset stomach, mild heartburn or stomach pain, diarrhea, constipation;
• bloating, gas;
• dizziness, headache, nervousness;
• skin itching or rash;
• blurred vision; or
• ringing in your ears.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect diclofenac?

Before taking diclofenac, tell your doctor if you are taking any of the following drugs:

• a blood thinner such as warfarin (Coumadin);
• cyclosporine (Neoral, Sandimmune);
• lithium (Eskalith, Lithobid);
• methotrexate (Rheumatrex, Trexall);
• diuretics (water pills) such as furosemide (Lasix).
• steroids (prednisone and others);
• aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others; or
• an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others.

If you are using any of these drugs, you may not be able to use diclofenac or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect diclofenac. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Diclofenac

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Methotrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.

Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis.

Methotrexate is usually given after other medications have been tried without successful treatment of symptoms.

Methotrexate may also be used for other purposes not listed in this medication guide.

Important information about methotrexate

Methotrexate can cause serious or life-threatening side effects on your liver, lungs, kidneys, and bone marrow (immune system). Do not take this medication in larger amounts, or take it for longer than prescribed. Follow the directions on your prescription label. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have liver disease (especially if caused by alcoholism), a blood cell or bone marrow disorder, or if you are breast-feeding a baby. This medication can cause birth defects in an unborn baby. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you are pregnant. Use an effective form of birth control, whether you are a man or a woman. Tell your doctor if you or your sexual partner become pregnant during treatment.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments.

There are many other medicines that can interact with methotrexate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Before taking methotrexate

Do not use this medication if you are allergic to methotrexate. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have:

• liver disease;
• alcoholism or cirrhosis of the liver;
• a blood cell disorder such as anemia (lack of red blood cells) or leukopenia (lack of white blood cells);
• a bone marrow disorder; or
• if you are breast-feeding a baby.

Methotrexate is sometimes used to treat cancer even when patients do have one of the conditions listed above. Your doctor will decide if this treatment is right for you.

Before using methotrexate, tell your doctor if you are allergic to any drugs, or if you have:

• kidney disease;
• liver disease;
• lung disease or pneumonia;
• stomach ulcers;
• any type of infection; or
• if you are receiving radiation treatments.

FDA pregnancy category X. Methotrexate can cause birth defects in an unborn baby. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Use birth control to prevent pregnancy while you are using methotrexate, whether you are a man or a woman. Methotrexate use by either parent may cause birth defects.

Before you start taking methotrexate, your doctor may want you to have a pregnancy test to make sure you are not pregnant.

If you are a man, use a condom to keep from causing a pregnancy while you are using methotrexate. Continue using condoms for at least 90 days after your treatment ends. If you are a woman, use an effective form of birth control while you are taking methotrexate, and for at least one cycle of ovulation after your treatment ends. Do not give this medicine to a child without the advice of a doctor.

Older adults may be more likely to have side effects from this medication.

How should I take methotrexate?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

You must use the correct dose of methotrexate for your condition. The medication is sometimes taken only once per week. Some people have died after taking methotrexate every day by accident. Ask your doctor if you have any questions about your dose of methotrexate or how often to take it.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

It is important to use methotrexate regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested, and you may need an occasional liver biopsy. Do not miss any scheduled appointments.

Store methotrexate at room temperature away from moisture and heat.

What happens if I miss a dose?

Call your doctor if you miss a dose of methotrexate.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of methotrexate can be fatal.

Overdose symptoms may include pale skin, easy bruising or bleeding, unusual weakness, mouth sores, nausea, vomiting, black or bloody stools, coughing up blood or vomit that looks like coffee grounds, and urinating less than usual or not at all.

Methotrexate side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using methotrexate and call your doctor at once if you have any of these serious side effects:

• dry cough, shortness of breath;
• diarrhea, vomiting, white patches or sores inside your mouth or on your lips;
• blood in your urine or stools;
• urinating less than usual or not at all;
• fever, chills, body aches, flu symptoms;
• sore throat and headache with a severe blistering, peeling, and red skin rash;
• pale skin, easy bruising or bleeding, weakness; or
• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• nausea, vomiting, upset stomach;
• dizziness, tired feeling;
• headache;
• bleeding of your gums; or
• blurred vision.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect methotrexate?

Before taking methotrexate, tell your doctor if you are using any of the following drugs:

• azathioprine (Imuran);
• chloramphenicol (Chloromycetin);
• hydroxychloroquine (Plaquenil, Quineprox);
• retinol, tretinoin (Retin-A), isotretinoin (Accutane);
• steroids (prednisone and others);
• sulfa drugs such as Azulfidine, Bactrim, or Septra;
• phenytoin (Dilantin);
• probenecid (Benemid);
• tetracycline (Brodspec, Panmycin, Sumycin, Tetracap);
• theophylline (Elixophyllin, Slo-Bid, Theobid, Theo-Dur);
• gold treatments such as auranofin (Ridura) or aurothioglucose (Solganol);
• oral diabetes medications such as acetohexamide (Dymelor), chlorpropamide (Diabinese), glipizide (Glucotrol), glimepiride (Amaryl), or tolbutamide (Orinase);
• penicillin antibiotic such as ampicillin (Principen), amoxicillin (Amoxil, Trimox), carbenicillin (Geocillin), cloxacillin (Cloxapen), dicloxacillin (Dynapen), nafcillin (Unipen), oxacillin (Bactocill), penicillamine (Cuprimine, Depen), or Bee-Pen, Pen-Vee K, Veetids;
• salicylates such as aspirin, Disalcid, Doan’s Pills, Dolobid, Salflex, Tricosal, and others; or
• NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others.

This list is not complete and there may be other drugs that can interact with methotrexate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Methotrexate

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Baclofen is a muscle relaxer and an antispastic agent.

Baclofen is used to treat muscle symptoms caused by multiple sclerosis, including spasm, pain, and stiffness.

Baclofen may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about baclofen?

Baclofen can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of baclofen. Do not use baclofen at a time when muscle tone is needed to assure safe balance and movement for certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone.

You may have withdrawal symptoms such as seizures or hallucinations, when you stop using baclofen after using it over a long period of time. Do not stop using this medication suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

What should I discuss with my healthcare provider before taking baclofen?

Do not use this medication if you are allergic to baclofen.

Before taking baclofen, tell your doctor if you are allergic to any drugs, or if you have:

• kidney disease;
• epilepsy or other seizure disorder; or
• a history of stroke or blood clots.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether baclofen passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more sensitive to the effects of this medicine.

Do not give this medication to a child younger than 12 years old.

How should I take baclofen?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

You may take baclofen with or without food.

Call your doctor if your muscle symptoms do not improve after 2 weeks of taking this medication.

You may have withdrawal symptoms such as seizures or hallucinations, when you stop using baclofen after using it over a long period of time. Do not stop using this medication suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

Store baclofen at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Baclofen overdose symptoms may include muscle weakness, vomiting, drowsiness, dilated or pinpoint pupils, weak or shallow breathing, fainting, or coma.

What are the possible side effects of baclofen?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• seizure (convulsions);
• confusion, hallucinations; or
• an uneven heartbeat.

Less serious baclofen side effects may include:

• drowsiness, dizziness, weakness, tired feeling;
• headache;
• sleep problems (insomnia);
• nausea, constipation; or
• urinating more often than usual.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect

What other drugs will affect baclofen?

There may be other drugs that can affect baclofen. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Baclofen

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Azathioprine lowers your body’s immune system. The immune system helps your body fight infections. The immune system can also fight or “reject” a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader.

Azathioprine is used to prevent your body from rejecting a transplanted kidney. It is also used to treat symptoms of rheumatoid arthritis.

Azathioprine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Imuran (azathioprine)?

Do not use this medication without telling your doctor if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Taking azathioprine may increase your risk of developing cancer. Talk with your doctor about your specific risk.

Azathioprine can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your kidney function may also to need to be tested. Do not miss any scheduled visits to your doctor.

Call your doctor at once if you have a fever, chills, sore throat, body aches, weakness, muscle pain, easy bruising or bleeding, mouth sores, pale stools, darkened urine, or severe nausea, vomiting, and diarrhea.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using azathioprine. You may need to stop using the medicine for a short time.

This medication can affect fertility (your ability to have children), whether you are a man or a woman. Talk with your doctor if you have concerns about this.

Do not receive a “live” vaccine while you are being treated with azathioprine and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you.

What should I discuss with my healthcare provider before taking Imuran (azathioprine)?

Do not take this medication if you are allergic to azathioprine.

Taking azathioprine may increase your risk of developing cancer. Talk with your doctor about your specific risk.

Before taking azathioprine, tell your doctor if you are allergic to any drugs, or if you have:

• liver disease;
• any type of viral, bacterial, or fungal infection; or
• if you have recently received chemotherapy treatments with medications such as cyclophosphamide (Cytoxan), chlorambucil (Leukeran), melphalan (Alkeran).

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use azathioprine without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

This medication can affect fertility (your ability to have children), whether you are a man or a woman. Talk with your doctor if you have concerns about this.

Azathioprine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Imuran (azathioprine)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take azathioprine with a full glass of water. Take azathioprine with food to lessen stomach upset.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using azathioprine. You may need to stop using the medicine for a short time.

Azathioprine can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your kidney function may also to need to be tested. Do not miss any scheduled appointments.

Store azathioprine at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

If you take this medicine once daily and you miss a dose, take the medicine as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled time to take the medication. Do not use extra medicine to make up the missed dose.

If you take this medicine more than once daily and you miss a dose, take the medicine as soon as you remember. If it is almost time for the next dose, take both doses together, then go back to your regular dosing schedule.

Call your doctor if you have missed more than one dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, stomach pain, diarrhea, bleeding, fever, chills, and other signs of infection.

Imuran (azathioprine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• pale skin, easy bruising or bleeding, unusual weakness;
• fever, chills, sore throat, body aches, weakness, muscle pain, flu symptoms;
• severe nausea, vomiting, or diarrhea;
• severe pain in your upper stomach spreading to your back, fast heart rate;
• pain or burning with urination;
• stomach pain, loss of appetite, dark urine, clay-colored stools, and jaundice (yellowing of the skin or eyes); or
• white patches or sores inside your mouth or on your lips.

Less serious side effects may include:

• mild upset stomach, nausea, diarrhea, loss of appetite;
• hair loss; or
• skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect Imuran (azathioprine)?

Before taking azathioprine, tell your doctor if you are taking, have taken, or need to take any of the following medicines:

• allopurinol (Zyloprim);
• mercaptopurine (Purinethol);
• methotrexate (Rheumatrex, Immunex);
• a blood thinner such as warfarin (Coumadin);
• cyclosporine (Neoral, Sandimmune);
• olsalazine (Dipentum), or sulfasalazine (Azulfidine);
• sulfamethoxasole and trimethoprim (Trimpex, Proloprim, Bactrim, Septra, others); or
• an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

This list is not complete and there may be other drugs that can interact with azathioprine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Decadron, a corticosteroid drug, is used to reduce inflammation and relieve symptoms in a variety of disorders, including rheumatoid arthritis and severe cases of asthma. It may be given to people to treat primary or secondary adrenal cortex insufficiency (lack of sufficient adrenal hormone). It is also given to help treat the following disorders:

Severe allergic conditions such as drug-induced allergies
Blood disorders such as various anemias
Certain cancers (along with other drugs)
Skin diseases such as severe psoriasis
Collagen (connective tissue) diseases such as systemic lupus erythematosus
Digestive tract disease such as ulcerative colitis
High serum levels of calcium associated with cancer
Fluid retention due to nephrotic syndrome (a condition in which damage to the kidneys causes the body to lose protein in the urine)
Eye diseases such as allergic conjunctivitis
Lung diseases such as tuberculosis (along with other drugs)

Most important fact about Decadron Tablets

Decadron lowers your resistance to infections and can make them harder to treat. Decadron may also mask some of the signs of an infection, making it difficult for your doctor to diagnose the actual problem.

How should you take Decadron Tablets?

Decadron should be taken exactly as prescribed by your doctor.

If you are taking large doses, your doctor may advise you to take Decadron with meals and to take antacids between meals, to prevent a peptic ulcer from developing.

Check with your doctor before stopping Decadron abruptly. If you have been taking the drug for a long time, you may need to reduce your dose gradually over a period of days or weeks.

The lowest possible dose should always be used, and as symptoms subside, dosage should be reduced gradually.

–If you miss a dose…

Take the forgotten dose as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to your regular schedule. Never try to “catch up” by doubling the dose.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Decadron.

• More common side effects may include:
  Abdominal distention, allergic reactions, blood clots, bone fractures and degeneration, bruises, cataracts, congestive heart failure, convulsions, “cushingoid” symptoms (moon face, weight gain, high blood pressure, emotional disturbances, growth of facial hair in women), excessive hairiness, fluid and salt retention, general feeling of illness, glaucoma, headache, hiccups, high blood pressure, high blood sugar, hives, increased appetite, increased eye pressure, increased pressure in head, increased sweating, increases in amounts of insulin or hypoglycemic medications needed in diabetes, inflammation of the esophagus, inflammation of the pancreas, irregular menstruation, loss of muscle mass, low potassium levels in blood (leading to symptoms such as dry mouth, excessive thirst, weak or irregular heartbeat, and muscle pain or cramps), muscle weakness, nausea, osteoporosis, peptic ulcer, perforated small and large bowel, poor healing of wounds, protruding eyeballs, suppression of growth in children, thin skin, tiny red or purplish spots on the skin, torn tendons, vertigo, weight gain

Special information if you are pregnant or breastfeeding

The effects of Decadron during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Infants born to mothers who have taken substantial doses of corticosteroids during pregnancy should be carefully watched for adrenal problems. Corticosteroids appear in breast milk and can suppress growth in infants. If Decadron is essential to your health, your doctor may advise you to stop breastfeeding until your treatment with Decadron is finished.

Recommended dosage

ADULTS

Your doctor will tailor your individual dose to the condition being treated. Initial doses range from 0.75 milligram to 9 milligrams a day.

After the drug produces a satisfactory response, your doctor will gradually lower the dose to the minimum effective level.

Overdosage

Reports of overdose with this medication are rare. However, if you suspect an overdose, seek medical treatment immediately.

Decadron

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