Granisetron blocks the actions of chemicals in the body that may cause nausea and vomiting.

Granisetron is used to prevent and treat nausea and vomiting associated with cancer chemotherapy, radiation therapy, and anesthesia used during surgery.

Granisetron may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Kytril (Granisetron)?

Take each oral dose with a full glass of water.

Granisetron can be taken with or without food.

What should I discuss with my healthcare provider before taking Kytril (Granisetron)?

Before taking granisetron, tell your doctor about any other medical conditions that you have and about any other prescription or over-the-counter medicines, including herbal products, that you take. You may need a dosage adjustment or special monitoring during treatment.

Granisetron is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take granisetron without first talking to your doctor if you are pregnant or if you are planning a pregnancy. It is not known whether granisetron passes into breast milk. Do not take granisetron without first talking to your doctor if you are breast-feeding a baby.

How should I take Kytril (Granisetron)?

Take granisetron exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each oral dose with a full glass of water.

To ensure you get the correct dose, measure the liquid form of granisetron with a dose-measuring spoon, cup, or dropper not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Granisetron can be taken with or without food.

Store granisetron at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

The only known symptom of a granisetron overdose is headache.

Kytril (Granisetron) side effects

If you experience any of the following uncommon but serious side effects, stop taking granisetron and seek emergency medical attention or contact your doctor immediately:

• an allergic reaction (swelling of the lips, tongue, or face, difficulty breathing, closing of the throat, or hives);
• irregular heartbeats; or
• muscle cramps or uncontrollable movements.

Other, less serious side effects may be more likely to occur. Continue to take granisetron and talk to your doctor if you experience

• headache;
• fatigue, drowsiness, or dizziness;
• anxiety or agitation; or
• diarrhea or constipation.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect granisetron?

Granisetron has not been reported to interact with other medicines. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with granisetron.

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