Quetiapine is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

Quetiapine is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression).

Quetiapine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Seroquel (Quetiapine)?

Quetiapine is not for use in psychotic conditions related to dementia. Quetiapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. Stop using quetiapine and call your doctor at once if you have the following symptoms: fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, uncontrolled muscle movements, symptoms that come on suddenly such as numbness or weakness, severe headache, and problems with vision, speech, or balance.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

What should I discuss with my healthcare provider before taking Seroquel (Quetiapine)?

Quetiapine is not for use in psychotic conditions related to dementia. Quetiapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

Before you take quetiapine, tell your doctor if you have:

• liver or kidney disease;
• heart disease, high blood pressure, heart rhythm problems;
• a history of heart attack or stroke;
• a thyroid disorder;
• seizures or epilepsy;
• high cholesterol or triglycerides;
• a personal or family history of diabetes; or
• trouble swallowing.

If you have any of these conditions, you may not be able to use quetiapine, or you may need a dosage adjustment or special tests during treatment.

Quetiapine may cause you to have high blood sugar (hyperglycemia). Talk to your doctor if you have any signs of hyperglycemia such as increased thirst or urination, excessive hunger, or weakness. If you are diabetic, check your blood sugar levels on a regular basis while you are taking quetiapine.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether quetiapine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give quetiapine to anyone younger than 18 years old without the advice of a doctor.

How should I take Seroquel (Quetiapine)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take each dose with a full glass of water. Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. Breaking the pill may cause too much of the drug to be released at one time.

To be sure this medication is helping your condition, your doctor will need to check your progress on a regular basis. Do not miss any scheduled appointments.

Store quetiapine tablets at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include extreme drowsiness, fast heart rate, feeling light-headed, or fainting.

Seroquel (Quetiapine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Other serious side effects include:

• fever, stiff muscles, confusion, sweating, fast or uneven heartbeats;
• jerky muscle movements you cannot control;
• sudden numbness or weakness, especially on one side of the body;
• sudden headache, confusion, problems with vision, speech, or balance;
• increased thirst, frequent urination, excessive hunger, or weakness;
• feeling like you might pass out; or
• urinating less than usual or not at all.

Less serious side effects may include:

• dizziness, drowsiness, or weakness;
• dry mouth, runny nose, sore throat;
• nausea, vomiting, stomach pain, constipation;
• blurred vision, headache, anxiety, agitation;
• breast swelling or discharge;
• missed menstrual periods; or
• weight gain.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect Seroquel (Quetiapine)?

Before taking quetiapine, tell your doctor if you are taking any of the following medicines:

• cimetidine (Tagamet);
• lorazepam (Ativan);
• rifabutin (Mycobutin) or rifampin (Rifadin, Rimactane, Rifater);
• steroids (prednisone and others);
• thioridazine (Mellaril);
• an antibiotic such as erythromycin (E-Mycin, E.E.S, Ery-Tab), fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox);
• medicine for depression or mental illness, such as fluoxetine (Prozac), haloperidol (Haldol), imipramine (Tofranil), or risperidone (Risperdal);
• a medication to treat high blood pressure or a heart condition; or
• seizure medication such as carbamazepine (Tegretol), divalproex (Depakote), phenobarbital (Luminal, Solfoton), phenytoin (Dilantin), or valproate (Depakene).

This list is not complete and there may be other drugs that can interact with quetiapine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Doxepin is in a group of drugs called tricyclic antidepressants. Doxepin affects chemicals in the brain that may become unbalanced.

Doxepin is used to treat symptoms of depression and/or anxiety associated with alcoholism, psychiatric conditions, or manic-depressive conditions.

Doxepin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Sinequan (Doxepin)?

Do not use this medication if you are allergic to doxepin, or if you have glaucoma or problems with urination. Do not use doxepin if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take doxepin before the MAO inhibitor has cleared from your body.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

What should I discuss with my healthcare provider before taking Sinequan (Doxepin)?

Do not use this medication if you are allergic to doxepin, or if you have glaucoma or problems with urination. Do not use doxepin if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take doxepin before the MAO inhibitor has cleared from your body.

Before taking doxepin, tell your doctor if you are allergic to any drugs, or if you have:

• bipolar disorder (manic-depression); or
• diabetes (doxepin may raise or lower blood sugar).

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether doxepin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give doxepin to anyone younger than 18 years old without the advice of a doctor.

How should I take Sinequan (Doxepin)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from this medication. Follow the directions on your prescription label.

Measure doxepin oral concentrate (liquid) with the special dose-measuring dropper provided. Do not use a regular table spoon. If you do not have a dose-measuring dropper, ask your pharmacist for one.

Empty the measured dose from the medicine dropper into a small glass (4 ounces) of water, milk, orange juice, grapefruit juice, tomato juice, prune juice, or pineapple juice. Do not use grape juice or a carbonated soft drink to mix doxepin oral concentrate. Stir the mixture and drink all of it right away. Do not save it for later use.

It may take a few weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve during treatment. Store doxepin at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of doxepin can be fatal.

Overdose symptoms may include uneven heartbeats, extreme drowsiness, agitation, vomiting, blurred vision, confusion, hallucinations, feeling hot or cold, muscle stiffness, feeling light-headed, fainting, seizure (convulsions), or coma.

Sinequan (Doxepin) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

• fast, pounding, or uneven heart rate;
• confusion, hallucinations, or seizure (convulsions);
• easy bruising or bleeding, unusual weakness;
• feeling light-headed, fainting;
• restless muscle movements in your eyes, tongue, jaw, or neck;
• tremors or uncontrollable shaking;
• urinating less than usual or not at all; or
• extreme thirst with headache, nausea, vomiting, and weakness.

Less serious side effects may include:

• nausea, vomiting, constipation, loss of appetite;
• dry mouth;
• weight changes;
• weakness, lack of coordination;
• numbness or tingly feeling;
• feeling dizzy, drowsy, or tired;
• sleep problems (insomnia), nightmares;
• blurred vision, headache, ringing in your ears;
• increased sweating;
• breast swelling (in men or women); or
• decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect Sinequan (Doxepin)?

Before taking doxepin, tell your doctor if you have used an “SSRI” antidepressant in the past 5 weeks, such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft).

Before taking doxepin, tell your doctor if you are currently using any of the following drugs:

• cimetidine (Tagamet) or;
• heart rhythm medications such as flecainide (Tambocor), propafenone (Rhythmol), or quinidine (Cardioquin, Quinidex, Quinaglute).

There are many other medicines that can interact with doxepin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

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BuSpar is an anti-anxiety medicine that affects chemicals in your brain that may become unbalanced and cause anxiety.

BuSpar is used in the treatment of anxiety disorders and and for short-term relief of the symptoms of anxiety, such as fear, tension, irritability, dizziness, pounding heartbeat, and other physical symptoms.

BuSpar may also be used for purposes not listed in this medication guide.

Important information about Buspar (Buspirone)

Do not use BuSpar if you are allergic to buspirone, or if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take BuSpar before the MAO inhibitor has cleared from your body. BuSpar can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It may increase some of the side effects caused by BuSpar.

Grapefruit and grapefruit juice may interact with BuSpar and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

BuSpar is usually taken for only a short time. Do not take this medication for longer than 4 weeks without your doctors advice.

What should I discuss with my healthcare provider before taking Buspar (Buspirone)?

Do not use BuSpar if you are allergic to buspirone, or if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take BuSpar before the MAO inhibitor has cleared from your body.

Before taking BuSpar, tell your doctor if you are allergic to any drugs, or if you have:

• kidney disease; or
• liver disease.

If you have any of these conditions, you may not be able to use BuSpar, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether BuSpar passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medication to a child younger than 18 years old.

How should I take Buspar (Buspirone)?

Take BuSpar exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

BuSpar is usually taken for only a short time. Do not take this medication for longer than 4 weeks without your doctors advice.

You may take BuSpar with or without food but take it the same way each time.

Some tablet forms of buspirone (Buspar Dividose) may need to be broken before you take the medicine. These tablets have special scored marks on them to make breaking the tablet easy. Do not use the tablet if it has not broken correctly and the piece is too big or too small. Follow your doctors instructions about how much of the tablet to take.

If you have been switched to BuSpar from another anxiety medication, you may need to slowly decrease your dose of the other medication rather than stopping suddenly. Some anxiety medications can cause withdrawal symptoms when you stop taking them suddenly after long-term use.

Store BuSpar at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, dizziness, drowsiness, blurred vision, and stomach pain.

What are the possible side effects of Buspar (Buspirone)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• feeling light-headed, fainting;
• fast or uneven heart rate;
• depressed mood, unusual thoughts or behavior; or
• lack of balance or coordination.

Less serious side effects may be more likely to occur, such as:

• drowsiness, dizziness, blurred vision;
• feeling restless;
• nausea, upset stomach;
• sleep problems (insomnia); or
• trouble concentrating.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect Buspar (Buspirone)?

Before taking BuSpar, tell your doctor if you are using any of the following drugs:

• medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril);
• dexamethasone (Decadron, Hexadrol);
• erythromycin (E-Mycin, E.E.S., Ery-Tab, Erythrocin);
• itraconazole (Sporanox), ketoconazole (Nizoral);
• ritonavir (Norvir);
• rifampin (Rifadin, Rimactane, Rifater);
• antibiotics such as capreomycin (Capastat), rifampin (Rifadin, Rimactane, Rifater), vancomycin (Vancocin, Vancoled);
• a calcium channel blocker such as diltiazem (Tiazac, Cartia, Cardizem) or verapamil (Calan, Covera, Isoptin, Verelan); or
• seizure medication such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), phenobarbital (Luminal, Solfoton).

If you are using any of these drugs, you may not be able to use BuSpar, or you may need dosage adjustments or special tests during treatment.

This list is not complete and there may be other drugs that can interact with BuSpar. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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