Rosiglitazone is an oral diabetes medicine that helps control blood sugar levels.

Rosiglitazone is for people with type 2 (non-insulin-dependent) diabetes. Rosiglitazone is sometimes used in combination with insulin or other medications, but it is not for treating type 1 diabetes.

Rosiglitazone is not recommended for use with insulin.

Rosiglitazone may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Avandia (Rosiglitazone)?

Do not use rosiglitazone if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Before taking rosiglitazone, tell your doctor if you have congestive heart failure or heart disease, a history of heart attack or stroke, liver disease, or eye problems caused by diabetes.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them, including hunger, headache, confusion, irritability, drowsiness, weakness, dizziness, tremors, sweating, fast heartbeat, seizure (convulsions), fainting, or coma (severe hypoglycemia can be fatal). Always keep a source of sugar available in case you have symptoms of low blood sugar. Some women using rosiglitazone have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control. Women may also be more likely than men to have bone fractures in the upper arm, hand, or foot while taking rosiglitazone. Talk with your doctor if you are concerned about this possibility. Taking certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with rosiglitazone.

What should I discuss with my healthcare provider before taking Avandia (Rosiglitazone)?

Do not use rosiglitazone if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before taking rosiglitazone, tell your doctor if you have:

• congestive heart failure or heart disease;
• a history of heart attack or stroke;
• liver disease; or
• eye problems caused by diabetes.

Taking certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with rosiglitazone. Some women using rosiglitazone have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control. Women may also be more likely than men to have bone fractures in the upper arm, hand, or foot while taking rosiglitazone. Talk with your doctor if you are concerned about this possibility. Categor?a C del embarazo por la FDA. No se conoce si rosiglitazone le puede hacer da?o al beb? nonato. Antes de usar esta medicina, d?gale a su m?dico usted est? embarazada o planea tener un embarazo durante su tratamiento. It is not known whether rosiglitazone passes into breast milk or if it could harm a nursing baby. Do not take rosiglitazone without first talking to your doctor if you are breast-feeding a baby.

How should I take Avandia (Rosiglitazone)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger or smaller amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Rosiglitazone is usually taken in the morning and evening. You may take the medicine with or without food.

Rosiglitazone is only part of a complete program of treatment that also includes diet, exercise, and weight control. Your doctor may also recommend other medicines to treat your diabetes.

It is important to use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your liver function may also need to be tested, and you may need regular eye exams. It is important that you not miss any scheduled visits to your doctor.

Your medication needs may change if you become sick or injured, if you have a serious infection, or if you have any type of surgery. Your doctor may want you to stop taking rosiglitazone for a short time if any of these situations affect you.

Take care not to let your blood sugar get too low, causing hypoglycemia. You may have hypoglycemia if you skip a meal, exercise too long, drink alcohol, or are under stress.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them:

• hunger, headache, confusion, irritability;
• drowsiness, weakness, dizziness, tremors;
• sweating, fast heartbeat;
• seizure (convulsions); or
• fainting, coma (severe hypoglycemia can be fatal).

Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

Store rosiglitazone at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. You may have signs of low blood sugar, such as hunger, headache, confusion, irritability, drowsiness, weakness, dizziness, tremors, sweating, fast heartbeat, seizure (convulsions), fainting, or coma.

Avandia (Rosiglitazone) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using rosiglitazone and call your doctor at once if you have any of these serious side effects:

• feeling short of breath, even with mild exertion;
• swelling or rapid weight gain;
• chest pain or heavy feeling, pain spreading to the arm or shoulder, sweating, general ill feeling;
• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• blurred vision;
• increased thirst or hunger, urinating more than usual; or
• pale skin, easy bruising or bleeding, weakness.

Less serious side effects may include:

• sneezing, runny nose, cough or other signs of a cold;
• headache;
• gradual weight gain;
• mild diarrhea; or
• back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Avandia (Rosiglitazone)?

You may be more likely to have hyperglycemia (high blood sugar) if you are taking rosiglitazone with other drugs that raise blood sugar. Drugs that can raise blood sugar include:

• isoniazid;
• diuretics (water pills);
• steroids (prednisone and others);
• phenothiazines (Compazine and others);
• thyroid medicine (Synthroid and others);
• birth control pills and other hormones;
• seizure medicines (Dilantin and others); and
• diet pills or medicines to treat asthma, colds or allergies.

You may be more likely to have hypoglycemia (low blood sugar) if you are taking rosiglitazone with other drugs that lower blood sugar. Drugs that can lower blood sugar include:

• nonsteroidal anti-inflammatory drugs (NSAIDs);
• aspirin or other salicylates (including Pepto-Bismol);
• sulfa drugs (Bactrim and others);
• a monoamine oxidase inhibitor (MAOI);
• beta-blockers (Tenormin and others); or
• probenecid (Benemid).

Some medications may interact with rosiglitazone. Tell your doctor if you are using any of the following drugs:

• gemfibrozil (Gemcor);
• rifampin (Rifater, Rifadin, Rimactane); or
• a nitrate drug for chest pain or heart problems, such as nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, and others), isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), or isosorbide mononitrate (Imdur, ISMO, Monoket).

This list is not complete and there may be other drugs that can interact with rosiglitazone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Glipizide is in a class of drugs called sulfonylureas. It is used to help control blood sugar levels.

Glipizide is used to treat type 2 diabetes along with diet, exercise, and insulin therapy, if necessary.

Glipizide may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Glucotrol XL (Glipizide)?

Treatment with glipizide may increase the risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin. Discuss with your doctor the risks and benefits of treatment with glipizide.

Know the signs and symptoms of low blood sugar (hypoglycemia), which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. Carry a piece of hard candy or glucose tablets with you to treat episodes of low blood sugar.

Follow diet, medication, and exercise routines closely. Changing any of them can affect blood sugar levels.

Do not change your dose of glipizide without first talking to your doctor. Avoid alcohol. It lowers blood sugar and may interfere with diabetes treatment. The Glucotrol XL extended release tablets (glipizide extended release tablets) should be swallowed whole. Do not chew, divide, or crush the tablets.

What should I discuss with my healthcare provider before taking Glucotrol XL (Glipizide)?

Before taking glipizide, tell your doctor if you

• have kidney disease;
• have liver disease;
• have thyroid disease;
• have type 1 diabetes;
• have a serious infection, illness, or injury; or
• need surgery.

You may not be able to take glipizide, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Patients 65 years of age and older may have a stronger reaction to glipizide and may require a reduced dose.

Glipizide is in the FDA pregnancy category C. This means that it is not known whether glipizide will be harmful to an unborn baby. Insulin is usually the drug of choice to control diabetes during pregnancy. Do not take glipizide without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether glipizide passes into breast milk. Do not take glipizide without first talking to your doctor if you are breast-feeding a baby.

How should I take Glucotrol XL (Glipizide)?

Take glipizide exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Glipizide is usually taken before breakfast if it is taken once a day, or before meals if it is taken multiple times each day. Follow your doctor’s instructions.

The Glucotrol XL extended release tablets (glipizide extended release tablets) should be swallowed whole. Do not chew, divide, or crush the tablets.

If you are taking Glucotrol XL extended release tablets (glipizide extended release tablets), do not be concerned if something that looks like a tablet occasionally appears in the stool. The medication is contained in a non-absorbable shell that has been specially designed to slowly release the drug so the body can absorb it. When this process is completed, the empty tablet is eliminated from the body.

It is important to take glipizide regularly to get the most benefit.

Do not change your dose of glipizide without first talking to your doctor.

Your healthcare provider may recommend regular monitoring of blood sugar levels with blood or urine tests.

Store glipizide at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected.

Symptoms of a glipizide overdose include hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, and coma.

Glucotrol XL (Glipizide) side effects

Stop taking glipizide and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives).

Other, less serious side effects from glipizide result mostly from blood sugar levels that are either too high or too low. You should be familiar with the symptoms of both high and low blood sugar levels and know how to treat both conditions. Also, be sure your family and close friends know how to help you in an emergency situation.

Low blood sugar may occur when too much glipizide is taken; when meals are missed or delayed; if you exercise more than usual; during illness, especially with vomiting or diarrhea; if you take other medications; after drinking alcohol; and in other situations.

Hypoglycemia or Low blood sugar has the following symptoms:

• shaking;
• headache;
• cold sweats;
• pale, cool skin;
• anxiety; and
• difficulty concentrating.

Keep hard, sugary candy; chocolate; fruit juice; or glucose tablets on hand to treat episodes of low blood sugar.

Increased blood sugar may occur when not enough glipizide is taken; if you eat significantly more food than usual; if you exercise less than usual; if you take other medications; during fever or other illness; and in other situations.

Hyperglycemia or High blood sugar has the following symptoms:

• increased thirst,
• increased hunger, and
• increased urination.

There may be an increased risk of death due to cardiovascular (heart and blood vessels) complications with the use of glipizide when compared to the treatment of diabetes with diet or diet plus insulin. The long-term use of glipizide should be discussed with your doctor.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Glucotrol XL (Glipizide)?

Many other medicines may increase or decrease the effects of glipizide or affect your condition. Before taking glipizide, tell your doctor if you are taking any of the following medicines:

• aspirin or another salicylate such as magnesium/choline salicylate (Trilisate), salsalate (Disalcid, others), choline salicylate (Arthropan), magnesium salicylate (Magan), or bismuth subsalicylate (Pepto-Bismol);
• a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis KT, Oruvail), diclofenac (Voltaren, Cataflam), etodolac (Lodine), indomethacin (Indocin), nabumetone (Relafen), oxaprozin (Daypro), naproxen (Anaprox, Naprosyn, Aleve), and others;
• a sulfa-based drug such as sulfamethoxazole-trimethoprim (Bactrim, Septra), sulfisoxazole (Gantrisin), or sulfasalazine (Azulfidine);
• a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil);
• a beta-blocker such as propranolol (Inderal), atenolol (Tenormin), acebutolol (Sectral), metoprolol (Lopressor), and others;
• a diuretic (water pill) such as hydrochlorothiazide (HCTZ, Hydrodiuril), chlorothiazide (Diuril), and others;
• a steroid medicine such as prednisone (Deltasone, Orasone, others), methylprednisolone (Medrol, others), prednisolone (Prelone, Pediapred, others), and others;
• a phenothiazine such as chlorpromazine (Thorazine), fluphenazine (Prolixin, Permitil), prochlorperazine (Compazine), promethazine (Phenergan), and others;
• phenytoin (Dilantin);
• isoniazid (Nydrazid); or
• prescription, over-the-counter, or herbal cough, cold, allergy, or weight loss medications.

You may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with glipizide or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

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Prandin is an oral diabetes medicine that helps control blood sugar levels. This medication lowers blood sugar by causing the pancreas to produce insulin.

Prandin is used together with diet and exercise to treat type 2 (non-insulin dependent) diabetes. Other diabetes medicines are sometimes used in combination with repaglinide if needed.

Prandin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Prandin (Repaglinide)?

Do not use this medication if you are allergic to repaglinide, if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). You should not use Prandin together with NPH insulin (such as isophane insulin).

Take care not to let your blood sugar get too low, causing hypoglycemia. You may have hypoglycemia if you skip a meal, exercise too long, drink alcohol, or are under stress.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them. Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. Severe hypoglycemia may cause loss of consciousness, seizures, or death. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection. If your blood sugar gets too high (hyperglycemia), you may feel very thirsty or hungry. You may also urinate more than usual. Call your doctor right away if you have any symptoms of hyperglycemia.

Prandin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

It is important to take Prandin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

What should I discuss with my doctor before taking Prandin (Repaglinide)?

Do not use this medication if you are allergic to repaglinide, if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). You should not use Prandin together with NPH insulin (such as isophane insulin).

Before taking Prandin, tell your doctor if you are allergic to any medications, or if you have liver disease. You may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Prandin passes into breast milk or if it could be harmful to a nursing baby. Do not take Prandin without telling your doctor if you are breast-feeding a baby.

How should I take Prandin (Repaglinide)?

Take Prandin exactly as it was prescribed for you. Do not take the medication in larger or smaller amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription.

Your dose needs may change if you are ill, if you have a fever or infection, or if you have surgery or a medical emergency. Do not change your dose of Prandin without first talking to your doctor. Take this medicine with a full glass of water.

Prandin is usually taken 2 to 4 times daily, within 30 minutes before eating a meal. Follow your doctor’s instructions. If you skip a meal, do not take your dose of Prandin. Wait until your next meal.

Take care not to let your blood sugar get too low, causing hypoglycemia. You may have hypoglycemia if you skip a meal, exercise too long, drink alcohol, or are under stress.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them. Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. Severe hypoglycemia may cause loss of consciousness, seizures, or death. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

To be sure this medication is helping your condition, you will need to check your blood sugar at home. Your blood will also need to be tested by your doctor on a regular basis. It is important that you not miss any scheduled visits to your doctor.

Prandin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

It is important to take Prandin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Store Prandin at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember, but only if you are getting ready to eat a meal. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include hunger, nausea, anxiety, cold sweats, weakness, drowsiness, loss of consciousness, and coma.

Prandin (Repaglinide) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• seizure (convulsions); or
• jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• runny or stuffy nose, sneezing, cough, cold or flu symptoms;
• diarrhea, nausea;
• back pain, headache;
• dizziness; or
• joint pain.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Prandin (Repaglinide)?

Before you take Prandin, tell your doctor if you also take gemfibrozil (Lopid) or itraconazole (Sporanox).

You may be more likely to have hyperglycemia (high blood sugar) if you are taking Prandin with other drugs that raise blood sugar. Drugs that can raise blood sugar include:

• isoniazid;
• diuretics (water pills);
• steroids (prednisone and others);
• phenothiazines (Compazine and others);
• thyroid medicine (Synthroid and others);
• birth control pills and other hormones;
• seizure medicines (Dilantin and others); and
• diet pills or medicines to treat asthma, colds or allergies.

You may be more likely to have hypoglycemia (low blood sugar) if you are taking Prandin with other drugs that lower blood sugar. Drugs that can lower blood sugar include:

• probenecid (Benemid);
• some nonsteroidal anti-inflammatory drugs (NSAIDs);
• aspirin or other salicylates (including Pepto-Bismol);
• sulfa drugs (Bactrim, Gantanol, Septra, and others);
• a monoamine oxidase inhibitor (MAOI); or
• beta-blockers (Tenormin and others).

This list is not complete and there may be other drugs that can interact with Prandin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Why is Starlix (Nateglinide) prescribed?

Starlix combats high blood sugar levels in people with type 2 diabetes (the kind that does not require insulin shots). Insulin speeds the transfer of sugar from the bloodstream to the body’s cells, where it’s burned to produce energy. In diabetes, the body either fails to make enough insulin, or proves unable to properly use what’s available. Starlix attacks the problem from the production angle, stimulating the pancreas to secrete more insulin.

Starlix can be used alone or combined with another diabetes drug, such as Actos, Avandia, or Glucophage, that tackles the other part of the problem, working to improve the body’s response to whatever insulin it makes. Starlix is prescribed only when diet and exercise—or the other drug alone—has failed to control blood sugar levels.

Most important fact about Starlix (Nateglinide)

Always remember that Starlix is an aid to, not a substitute for, good diet and exercise. Failure to follow a sound diet and exercise plan can lead to serious complications, such as dangerously high or low blood sugar levels. Remember, too, that Starlix is not an oral form of insulin, and cannot be used in place of insulin shots.

How should you take Starlix (Nateglinide)?

Starlix should be taken before each meal, anywhere from 30 minutes to the moment before you begin to eat. If you skip a meal, skip your Starlix dose as well; wait until your next meal before taking the medication.

• If you miss a dose…
  Wait until your next meal, then take your regular dose. Never take 2 doses at the same time.

• Storage instructions…
  Store at room temperature in a tightly closed container.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Starlix.

• Side effects may include:
  Back pain, diarrhea, dizziness, flu-like symptoms, joint infection, upper respiratory infection

Starlix, like all oral diabetes drugs, can cause hypoglycemia (low blood sugar). This risk is increased by missed meals, alcohol, other diabetes medications, and excessive exercise. Hypoglycemia is more likely in older or malnourished people and those with poorly functioning adrenal or pituitary glands. To avoid low blood sugar, take Starlix only at meals and closely follow the dietary and exercise regimen suggested by your doctor.

• Symptoms of mild low blood sugar may include:
  Blurred vision, cold sweats, dizziness, fast heartbeat, fatigue, headache, hunger, light-headedness, nausea, nervousness

• Symptoms of more severe low blood sugar may include:
  Coma, disorientation, pale skin, seizures, shallow breathing

Mild hypoglycemia can usually be corrected by eating sugar or a sugar-based product. If symptoms of severe low blood sugar develop, contact your doctor immediately. Severe hypoglycemia should be considere

Why should Starlix (Nateglinide) not be prescribed?

If you have type 1 (insulin-dependent) diabetes, you cannot use Starlix. The drug also cannot be used for diabetic ketoacidosis (a life-threatening medical emergency caused by insufficient insulin and marked by excessive thirst, nausea, fatigue, pain below the breastbone, and fruity-smelling breath).

If you are already taking a drug that promotes insulin secretion, such as Micronase, you should not switch to Starlix or add it to your current drug. In addition, Starlix is not for you if you have been taking other antidiabetic drugs for a long time, or if Starlix gives you an allergic reaction.

Possible food and drug interactions when taking Starlix (Nateglinide)

If Starlix is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Starlix with the following:
Airway-opening drugs such as Alupent and Proventil
Aspirin
Beta blockers such as the blood pressure medications Inderal and Tenormin
Corticosteroids such as prednisone (Deltasone)
Decongestants such as Sudafed
MAO inhibitors such as the antidepressants Nardil and Parnate
Nonsteroidal anti-inflammatory drugs such as Advil, Motrin, and Naprosyn
Salicylates such as the arthritis drugs Disalcid and Trilisate
Thiazide diuretics such as the water pills Esidrix and HydroDIURIL
Thyroid medications such as Synthroid

Be careful about drinking alcohol, since excessive alcohol consumption can cause low blood sugar. Also be careful when having a liquid meal; it could reduce the effectiveness of the drug.

Special information if you are pregnant or breastfeeding

Because the effects of Starlix on the unborn child have not been adequately studied, Nateglinide should not be used during pregnancy. Since studies suggest the importance of maintaining normal blood sugar levels during pregnancy, you may need to take insulin instead.

It is not known whether Starlix appears in breast milk. Because of potential harm to the baby, you’ll need to choose between breastfeeding and continuing treatment with Starlix.

Recommended dosage for Starlix (Nateglinide)

ADULTS

Take Starlix shortly before meals. The usual dose of Starlix, whether taken alone or combined with Actos, Avandia, or Glucophage, is 120 milligrams three times a day. If your doctor finds that your glycosylated hemoglobin (HbA1C) levels are near normal before you start taking the drug, you may use the lower dose of 60 milligrams three times a day.

Overdosage

An overdose of Starlix can cause low blood sugar. (For symptoms, see “What side effects may occur?”) Mild hypoglycemia can usually be corrected by eating sugar or a sugar-based product. If your symptoms persist or worsen, seek medical attention immediately.

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Glycemil is specifically formulated to help prevent the health problems associated wsith high blood sugar levels by:

• Helping blunt the insulin spike caused by high glycemic index foods;
• Helping regulate blood sugar levels;
• Helping lower insulin resistance;
• Helping regulate insulin production.

How Taken

As a dietary supplement, take one (1) capsule before each meal. Do not exceed three (3) capsules per day.

Drug Class and Mechanism

High Blood Sugar Levels can be bad news, leading to a number of serious health problems including excess weight gain (obesity), insulin resistance syndrome, diabetes and heart disease. Typically, controlling blood sugar levels has been done through diet, exercise, insulin injections for diabetics, and other prescription medications, some of which can have side effects that include nausea, diarrhea, weight gain, liver damage and respiratory infections.

The good news is that Lazarus Labs has just released Glycemil, the pharmaceutical quality, non-prescription product clinically proven to help control blood sugar levels – without dangerous side effects.

Missed Dose

If you miss a dose of Glycemil, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Storage

Store Glycemil at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Glycemil out of the reach of children and away from pets.

Warnings/Precautions

No absolute contraindications.

Possible Side Effects

This product contains only 100% pure pharmaceutical grade ingredients and is regularly tested to ensure the safety and quality. Each ingredient has been approved as safe by the FDA and all appear on the FDAs GRAS (Generally Recognized As Safe) list.

More Information

High blood sugar (glucose) levels are associated with a number of serious health problems including obesity, heart disease and diabetes. Diabetes is a disease characterized by the body inability to properly regulate levels of blood sugar by producing or adequately utilizing insulin. It affects over 20,000,000 people in the U.S. alone and is associated with an increased risk of life-threatening complications such as a heart attack, stroke, and/or kidney disease. At present, diabetes is the third leading cause of death in the United States.

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Fluoxetine is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Fluoxetine affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive symptoms.

Fluoxetine is used to treat major depressive disorder, bulimia nervosa (an eating disorder) obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder (PMDD).

Fluoxetine may also be used for purposes other than those listed in this medication guide.

Important information about Fluoxetine

Do not take fluoxetine together with pimozide (Orap), thioridazine (Mellaril), or a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking fluoxetine, do not stop taking the medication without first talking to your doctor.

Before taking Fluoxetine

Do not use fluoxetine if you are using any of the following drugs:

• pimozide (Orap);
• thioridazine (Mellaril); or
• an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam).

Serious and sometimes fatal reactions can occur when these medicines are taken with fluoxetine. You must wait at least 14 days after stopping an MAO inhibitor before you can take fluoxetine. You must wait 5 weeks after stopping fluoxetine before you can take thioridazine (Mellaril) or an MAOI.

Before taking fluoxetine, tell your doctor if you are allergic to any drugs, or if you have:

• cirrhosis of the liver;
• kidney disease;
• diabetes;
• seizures or epilepsy;
• bipolar disorder (manic depression); or
• a history of drug abuse or suicidal thoughts.

If you have any of these conditions, you may not be able to use fluoxetine, or you may need a dosage adjustment or special tests.

You may have thoughts about suicide while taking an antidepressant, such as fluoxetine, especially if you are younger than 24 years old. Tell your doctor if you have worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking fluoxetine, do not stop taking the medication without first talking to your doctor. Fluoxetine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give fluoxetine to anyone younger than 18 years old without a doctor’s advice. Fluoxetine is the only antidepressant that is FDA-approved for use in children with depression.

How should I take Fluoxetine?

Take fluoxetine exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from fluoxetine.

Do not break, chew, or open an extended-release capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.

Measure the liquid form of fluoxetine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

It may take 4 weeks or longer before you start feeling better. Do not stop using fluoxetine without first talking to your doctor. You may have unpleasant side effects if you stop taking this medication suddenly.

To treat premenstrual dysphoric disorder, the usual dose of fluoxetine is once daily while you are having your period, or 14 days before you expect your period to start. Follow your doctor’s instructions.

Store fluoxetine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take extra medicine to make up the missed dose.

If you miss a dose of Prozac Weekly, take the missed dose as soon as you remember and take the next dose 7 days later. However, if it is almost time for the next regularly scheduled weekly dose, skip the missed dose and take the next one as directed.Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have taken too much of this medication. Overdose may cause nausea, vomiting, fever, sleepiness, rapid or uneven heartbeat, confusion, fainting, seizures, or coma.

Fluoxetine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you experience any of these serious side effects from using fluoxetine :

• severe blistering, peeling, and red skin rash;
• very stiff (rigid) muscles, high fever, sweating, fast or uneven heartbeats, tremors, overactive reflexes;
• nausea, vomiting, diarrhea, loss of appetite, feeling unsteady, loss of coordination; or
• headache, trouble concentrating, memory problems, weakness, confusion, hallucinations, fainting, seizure, shallow breathing or breathing that stops.

Less serious fluoxetine side effects may include:

• cold symptoms such as stuffy nose, sneezing, sore throat;
• drowsiness, dizziness, feeling nervous;
• mild nausea, upset stomach, constipation;
• increased appetite, weight changes;
• sleep problems (insomnia);
• decreased sex drive, impotence, or difficulty having an orgasm; or
• dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Fluoxetine?

Talk to your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin and NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with fluoxetine may cause you to bruise or bleed easily.

Before taking fluoxetine, tell your doctor if you are using any of the following medicines:

• alprazolam (Xanax);
• clozapine (Clozaril, Fazaclo);
• digitoxin (Crystodigin);
• flecainide (Tambocor);
• haloperidol (Haldol);
• seizure medication such as phenytoin (Dilantin) or carbamazepine (Tegretol);
• tryptophan (also called L-tryptophan);
• vinblastine (Velban);
• a blood thinner such as warfarin (Coumadin);
• almotriptan (Axert), frovatriptan (Frova), sumatriptan (Imitrex), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig); or
• any other antidepressants such as amitriptyline (Elavil), escitalopram (Lexapro), imipramine (Tofranil), sertraline (Zoloft), and others.

This list is not complete and there may be other drugs that can interact with fluoxetine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Trazodone is a tetracyclic antidepressant medication. It is thought to increase the activity of one of the brain chemicals (serotonin) which may become unbalanced and cause depression. It may also be used for relief of anxiety disorders (eg, sleeplessness, tension) and chronic pain.

Trazodone is used to treat depression.

Trazodone may also be used for other purposes not listed in this medication guide.

Important information about Trazodone

Before taking trazodone, tell your doctor if you are allergic to any drugs, or if you have bipolar disorder (manic depression), schizophrenia or other psychiatric illness, a history of drug abuse or suicidal thoughts, or if you have recently had a heart attack.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Trazodone works best if you take it after a meal or a snack. Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Trazodone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Do not drink alcohol while you are taking trazodone. Alcohol can increase drowsiness and dizziness caused by trazodone. Stop taking trazodone and call your doctor at once if you have a penis erection that is painful or lasts 4 hours or longer. This is a medical emergency and could lead to a serious condition that must be corrected with surgery.

Before taking Trazodone

Do not use this medication if you are allergic to trazodone.

Before using trazodone, tell your doctor if you are allergic to any drugs, or if you have:

• bipolar disorder (manic depression);
• schizophrenia, or other psychiatric illness;
• a history of drug abuse or suicidal thoughts; or
• if you have recently had a heart attack.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take trazodone.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Trazodone may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give trazodone to anyone younger than 18 years old without the advice of a doctor.

How should I take Trazodone?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Trazodone works best if you take it after a meal or a snack.

You may need to take this medicine at bedtime, because trazodone can cause drowsiness. Follow your doctor’s instructions.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using trazodone. You may need to stop using the medicine for a short time. It may take up to 2 weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 2 weeks of treatment. You may need to take trazodone for several weeks or months to control your depression symptoms.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

Store trazodone at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of trazodone can be fatal when it is taken with alcohol, barbiturates such as phenobarbital, or sedatives such as diazepam (Valium).

Overdose symptoms may include drowsiness, vomiting, penis erection that is painful or prolonged, uneven heart rate, seizure (black-out or convulsions), or breathing that slows or stops.

Trazodone side effects

Stop taking trazodone and call your doctor at once if you have a penis erection that is painful or lasts 4 hours or longer. This is a medical emergency and could lead to a serious condition that must be corrected with surgery. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

• feeling light-headed, fainting;
• fever, chills, body aches, flu symptoms; or
• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or
• problems with urination.

Less serious trazodone side effects may be more likely to occur, such as:

• dizziness or drowsiness;
• headache;
• sleep problems (insomnia);
• dry mouth, stuffy nose;
• nausea, vomiting, loss of appetite;
• diarrhea or constipation;
• muscle pain;
• loss of coordination; or
• blurred vision.

This is not a complete list of trazodone side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Trazodone?

Before taking trazodone, tell your doctor if you are using any of the following drugs:

• an HIV medicine such as indinavir (Crixivan) or ritonavir (Norvir);
• an antibiotic such as ketoconazole (Nizoral) or itraconazole (Sporanox);
• digoxin (Lanoxin, Lanoxicaps);
• seizure medicine such as carbamazepine (Carbatrol, Tegretol) or phenytoin (Dilantin);
• warfarin (Coumadin); or
• if you have taken an MAO inhibitor within the past 14 days, such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).

This list is not complete and there may be other drugs that can interact with trazodone. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

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Haloperidol is an antipsychotic medication. It works by changing the actions of chemicals in your brain.

Haloperidol is used to treat schizophrenia. It is also used to control motor and speech tics in people with Tourette’s syndrome.

Haloperidol may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Haldol (Haloperidol)?

Haloperidol is not for use in psychotic conditions related to dementia. Haloperidol may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. Haloperidol can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol. It can increase drowsiness or dizziness caused by haloperidol.

What should I discuss with my healthcare provider before taking Haldol (Haloperidol)?

Haloperidol is not for use in psychotic conditions related to dementia. Haloperidol may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not use this medication if you are allergic to haloperidol, or have certain conditions. Be sure your doctor knows if you have Parkinson’s disease.

Before taking haloperidol, tell your doctor if you are allergic to any drugs, or if you have:

• liver disease;
• kidney disease;
• heart disease, angina (chest pain);
• a thyroid disorder;
• epilepsy or other seizure disorder;
• a personal or family history of “Long QT syndrome”;
• an electrolyte imbalance such as low potassium or magnesium levels in your blood.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take haloperidol.

It is not known whether haloperidol is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Haloperidol can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Haldol (Haloperidol)?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Taking too much of this medication can cause a serious heart rhythm disorder or sudden death. Never take more than your prescribed dose. Take haloperidol with a full glass of water.

Haloperidol can be taken with or without food.

It may take several weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Do not stop using haloperidol suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication. Store haloperidol at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of haloperidol can be fatal.

Overdose symptoms may include extreme drowsiness, feeling like you might pass out, tremors, and uncontrolled muscle movements in your eyes, tongue, jaw, or neck.

Haldol (Haloperidol) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• dizziness, fainting, fast or pounding heartbeat;
• restless muscle movements in your eyes, tongue, jaw, or neck;
• tremor (uncontrolled shaking);
• fever, stiff muscles, confusion, sweating, fast or uneven heartbeats;
• stabbing chest pain, feeling short of breath, cough with yellow or green mucus;
• sudden mood changes;
• confusion, agitation, hallucinations, unusual thoughts or behavior; or
• jaundice (yellowing of your skin or eyes).

Less serious side effects may include:

• headache, dizziness, drowsiness;
• sleep problems (insomnia);
• feeling restless or anxious;
• mild skin rash or itching;
• breast enlargement, irregular menstrual periods, loss of interest in sex; or
• dry mouth, blurred vision, urinating less than usual.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Haldol (Haloperidol) Dosing Information

Usual Adult Dose for ICU Agitation:

Haloperidol lactate:
IV, intermittent: 0.03 to 0.15 mg/kg IV (2 to 10 mg) every 30 minutes to 6 hours.
IV, infusion: 3 to 25 mg/hour by continuous IV infusion, has been used for ventilator patients with agitation and delirium.

Usual Adult Dose for Dementia:

For non-psychotic behavioral problems related to dementia:
Initial dose: 0.5 mg orally 2 to 3 times daily.
Maintenance dose: 0.5 to 3 mg orally 2 times a day.

Usual Adult Dose for Mania:

Oral:
Initial dose: 0.5 to 5 mg orally 2 to 3 times a day
Maintenance dose: 1 to 30 mg/day in 2 or 3 divided doses. Infrequently, haloperidol has been used in doses above 100 mg for severely resistant patients; however, the limited clinical usage has not demonstrated the safety of prolonged administration of such doses.

Parenteral:
Haloperidol Lactate:
2 to 5 mg IM or IV for prompt control. May repeat every 4 to 8 hours. Doses up to 8 to 10 mg may be given intramuscularly. Acutely agitated patients may require hourly injections.

Usual Adult Dose for Nausea/Vomiting:

Oral:
1 to 5 mg orally every 4 to 6 hours as needed.

Parenteral:
Haloperidol lactate:
1 to 5 mg IM or IV every 4 to 6 hours as needed.

Usual Adult Dose for Psychosis:

Oral:
Initial dose: 0.5 to 5 mg orally 2 to 3 times a day.
Maintenance dose: 1 to 30 mg/day in 2 to 3 divided doses. Daily doses of up to 100 mg have been used. Infrequently, haloperidol has been used in doses above 100 mg for severely resistant patients; however, the limited clinical usage has not demonstrated the safety of prolonged administration of such doses.

Parenteral:
Haloperidol lactate:
2 to 5 mg IM or IV for prompt control. May repeat every 4 to 8 hours. Doses up to 8 to 10 mg may be given intramuscularly. Acutely agitated patients may require hourly injections.

Haloperidol decanoate:
Initial dose: 10 to 15 times the previous oral daily dose intramuscularly every 3 to 4 weeks. The initial dose should not exceed 100 mg and the balance should be given in 3 to 7 days. There is limited experience with doses greater than 450 mg/month. Do not give IV.

Usual Adult Dose for Tourette’s Syndrome:

Initial dose: 0.5 to 2 mg orally 2 to 3 times a day.
Maintenance dose: May increase every 5 to 7 days to 3 to 5 mg 2 to 3 times daily for more severe or resistant cases.

Usual Geriatric Dose for not applicable:

Delirium: 0.25 to 0.5 mg orally or IM every 4 hours.

Usual Geriatric Dose for Psychosis:

Oral:
Initial dose: 0.5 to 2 mg orally 2 to 3 times a day.
Maintenance dose: 1 to 30 mg/day in 2 to 3 divided doses. Daily doses of up to 100 mg have been used. Infrequently, haloperidol has been used in doses above 100 mg for severely resistant patients; however, the limited clinical usage has not demonstrated the safety of prolonged administration of such doses. The lowest possible effective dose should be used since geriatric patients are more sensitive to the adverse effects of haloperidol (e.g., tardive dyskinesia).

Parenteral:
Haloperidol Lactate:
2 to 5 mg IM or IV for prompt control. May repeat every 4 to 8 hours. Doses up to 8 to 10 mg may be given intramuscularly. Acutely agitated patients may require hourly injections.

Usual Pediatric Dose for Psychosis:

Oral:
2 years or younger or less than 15 kg: Use is not recommended.
3 to 12 years and 15 to 40 kg:
Initial dose: 0.5 mg/day orally in 2 to 3 divided doses.
Maintenance dose: The daily dose may be increased every 5 to 7 days in 0.25 to 0.5 mg increments. The usual range is 0.05 to 0.15 mg/kg/day in 2 to 3 divided doses. There is little evidence that behavior improvement is further enhanced by doses greater than 6 mg/day.
13 to 18 years and greater than 40 kg:
Initial dose: 0.5 to 5 mg orally 2 to 3 times a day.
Maintenance dose: 1 to 30 mg/day in 2 to 3 divided doses. Daily doses of up to 100 mg have been used. Infrequently, haloperidol has been used in doses above 100 mg for severely resistant patients; however, the limited clinical usage has not demonstrated the safety of prolonged administration of such doses.

Parenteral:
Haloperidol lactate:
5 years younger: Use is not recommended.
6 to 12 years: 1 to 3 mg IM every 4 to 8 hours as needed (maximum 0.15 mg/kg/day). Patients should be switched to oral therapy as soon as possible.
13 to 18 years: 2 to 5 mg IM every 4 to 8 hours as needed.

Haloperidol decanoate:
17 year or younger: Safety and efficacy have not been established.

Usual Pediatric Dose for Tourette’s Syndrome:

2 years or younger or less than 15 kg: Use is not recommended.
3 to 12 years and 15 to 40 kg:
Initial dose: 0.5 mg/day orally in 2 to 3 divided doses.
Maintenance dose: The daily dose may be increased weekly in 0.25 to 0.5 mg increments up to 0.05 to 0.075 mg/kg/day. There is little evidence that behavior improvement is further enhanced by doses greater than 6 mg/day.
13 to 18 years and greater than 40 kg: 1 to 2 mg orally 2 to 3 times a day.

Usual Pediatric Dose for not applicable:

Oral:
2 years or younger or less than 15 kg: Use is not recommended.
3 to 12 years and 15 to 40 kg:
Agitation/Hyperkinesia: 0.01 to 0.03 mg/kg/day, up to a maximum of 0.15 mg/kg/day.
Autism: 0.5 to 4 mg/day.
13 to 18 years and greater than 40 kg: 0.5 to 5 mg orally 2 to 3 times a day.

Intramuscular:
Haloperidol lactate:
5 years or younger: Use is not recommended.
6 to 12 years: 1 to 3 mg IM every 4 to 8 hours as needed (maximum 0.15 mg/kg/day). Patients should be switched to oral therapy as soon as possible.
13 to 18 years: 2 to 5 mg IM every 4 to 8 hours as needed.

What other drugs will affect Haldol (Haloperidol)?

Before using haloperidol, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by haloperidol.

The following drugs can interact with haloperidol. Tell your doctor if you are using any of these:

• lithium (Eskalith, Lithobid, others);
• a blood thinner such as warfarin (Coumadin); or
• rifampin (Rifadin, Rifamate, Rimactane).

This list is not complete and there may be other drugs that can interact with haloperidol. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

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5- HTP provides the quickest, most effective, and most consistent overall results in treating insomnia. 5-HTP (5-Hydroxy-l-tryptophan) is an amino acid that converts into two chemicals called Serotonin and Melatonin. Melatonin is a sleep-inducing hormone, produced by the body, and Serotonin is a calming neurotransmitter. Both help aid in sleep, reliving worries, and allowing you to clear your mind.

Benefits:

• Enhanced Sleep;
• Relieved Anxiety;
• Relieve symptoms of SAD (Seasonal Affective Disorder).

How Taken

Take 1 to 3 mg, thirty to forty-five minutes before retiring. Start with the lower dose for at least three days, and then consider increasing the dose if results are not what you expected.

Drug Class and Mechanism

5-HTP improves the quality of sleep. More importantly, clinical studies show that 5- HTP is also useful in the treatment of sleep disorders other than insomnia.

5-HTP increases REM sleep significantly (typically by about 25 percent) while simultaneously increasing deep sleep stages 3 and 4 without increasing total sleep time. 5- HTP accomplishes this by shortening the amount of time you spend in sleep stages 1 and 2, which in certain ways are the least important stages of the cycle. The higher the dose, the more time spent in REM.

By shifting the balance of the sleep cycle, 5-HTP makes sleep more restful and rejuvenating. Instead of waking feeling tired, worn out, people taking 5- HTP feel vibrant, well rested, and ready to take on the challenges of the day. When we sleep more deeply and dream more efficiently, we wake in the morning with our physical and psychological batteries fully charged.

Missed Dose

If you miss a dose of 5-HTP, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Storage

Store 5-HTP at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep 5-HTP out of the reach of children and away from pets.

Warnings/Precautions

5-HTP should not be taken with other antidepressants, MAO inhibitors, weight loss products, St.John’s wort, or by pregnant women, unless recommended by a health practitioner. Vitamin B6 should not be taken at the same time, although it is helpful if taken about 6 hours earlier than the 5-HTP.

Possible Side Effects

Aside from the risk of consuming impure 5HTP, the supplement can cause side effects, though most are generally mild. 5 HTP side effects include:

• nausea;
• constipation;
• headaches.

More Information

5-HTP may prove to be better than melatonin. Several clinical studies have shown 5-HTP to produce good results in promoting and maintaining sleep in normal subjects as well as those experiencing insomnia (11-14). One of the key benefits with 5-HTP in the treatment of insomnia is its ability to increase sleep quality.

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Vitamin B1 is a supplement used to treat Vitamin B1 deficiency, a condition caused by not having enough Vitamin B1 in the body. Vitamin B1 may also be used to improve memory, such as in Alzheimer’s disease. A heart problem called congestive heart failure may be treated with Vitamin B1. A person who is trying to stop drinking alcohol may be helped with Vitamin B1. Beriberi (bear-ee-bear-ee), a nerve disease caused by Vitamin B1 deficiency, may be treated with Vitamin B1. Other uses for Vitamin B1 include the treatment of nerve problems caused by diabetes. Vitamin B1 may be used to treat Wernicke’s encephalopathy (en-cef-uh-LOP-uh-thee), a brain disease. In children, maple syrup urine disease may be treated with Vitamin B1.

Other names for Vitamin B1 include: thiamine or Aneurine hydrochloride.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you

• are taking medicine or are allergic to any medicine (prescription or over-the-counter (OTC) or dietary supplement)
• are pregnant or plan to become pregnant while using this medicine
• are breastfeeding
• have other health problems, such as high blood pressure or heart or blood vessel disease

Dosage:

Talk with your doctor, pharmacist, or nurse about how much Vitamin B1 you should take. The amount depends on the strength of the medicine and the reason you are taking Vitamin B1. If you are using this medicine without instructions from your caregiver, follow the directions on the label. Do not take more Vitamin B1 or take it more often than what is written on the directions.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.

Drug and Food Interactions:

Do not take Vitamin B1 without talking to your doctor first.

Warnings:

• Before taking Vitamin B1, tell your doctor if you are pregnant or breastfeeding

Side Effects:

Stop taking your medicine right away and talk to your doctor if you have any of the following side effects.

• Allergic reaction: Itching or hives, swelling in your face or hand, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, or rash.

Other Side Effects:

You may have the following side effects, but this medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.

• Pain in the area of your arm where you received Vitamin B1 intravenously (through a needle into a vein).

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