Diclofenac is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac works by reducing hormones that cause inflammation and pain in the body.

Diclofenac is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis.

Diclofenac may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking diclofenac?

Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Do not use this medication if you are allergic to diclofenac, or if you have a history of allergic reaction to aspirin or other NSAIDs.

Before taking diclofenac, tell your doctor if you are allergic to any drugs, or if you have:

• a history of heart attack, stroke, or blood clot;
• heart disease, congestive heart failure, high blood pressure;
• a history of stomach ulcers or bleeding;
• liver or kidney disease,
• asthma;
• polyps in your nose;
• a bleeding or blood clotting disorder; or
• if you smoke.

If you have any of these conditions, you may not be able to use diclofenac, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking diclofenac during the last 3 months of pregnancy may result in birth defects. Do not take diclofenac during pregnancy unless your doctor has told you to. Diclofenac can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to a child without the advice of a doctor.

How should I take diclofenac?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

If you switch brands of diclofenac, your dose needs may change. Follow your doctors instructions about how much medicine to take.

Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.

If you take diclofenac for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.

Store diclofenac at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a diclofenac overdose may include nausea, vomiting, stomach pain, drowsiness, black or bloody stools, coughing up blood, shallow breathing, fainting, or coma.

What are the possible side effects of diclofenac?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking diclofenac and seek medical attention or call your doctor at once if you have any of these serious side effects:

• chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
• black, bloody, or tarry stools;
• coughing up blood or vomit that looks like coffee grounds;
• swelling or rapid weight gain;
• urinating less than usual or not at all;
• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
• bruising, severe tingling, numbness, pain, muscle weakness; or
• fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions).

Keep taking diclofenac and talk to your doctor if you have any of these less serious side effects:

• upset stomach, mild heartburn or stomach pain, diarrhea, constipation;
• bloating, gas;
• dizziness, headache, nervousness;
• skin itching or rash;
• blurred vision; or
• ringing in your ears.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect diclofenac?

Before taking diclofenac, tell your doctor if you are taking any of the following drugs:

• a blood thinner such as warfarin (Coumadin);
• cyclosporine (Neoral, Sandimmune);
• lithium (Eskalith, Lithobid);
• methotrexate (Rheumatrex, Trexall);
• diuretics (water pills) such as furosemide (Lasix).
• steroids (prednisone and others);
• aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others; or
• an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others.

If you are using any of these drugs, you may not be able to use diclofenac or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect diclofenac. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Diclofenac

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Methotrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.

Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis.

Methotrexate is usually given after other medications have been tried without successful treatment of symptoms.

Methotrexate may also be used for other purposes not listed in this medication guide.

Important information about methotrexate

Methotrexate can cause serious or life-threatening side effects on your liver, lungs, kidneys, and bone marrow (immune system). Do not take this medication in larger amounts, or take it for longer than prescribed. Follow the directions on your prescription label. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have liver disease (especially if caused by alcoholism), a blood cell or bone marrow disorder, or if you are breast-feeding a baby. This medication can cause birth defects in an unborn baby. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you are pregnant. Use an effective form of birth control, whether you are a man or a woman. Tell your doctor if you or your sexual partner become pregnant during treatment.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments.

There are many other medicines that can interact with methotrexate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Before taking methotrexate

Do not use this medication if you are allergic to methotrexate. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have:

• liver disease;
• alcoholism or cirrhosis of the liver;
• a blood cell disorder such as anemia (lack of red blood cells) or leukopenia (lack of white blood cells);
• a bone marrow disorder; or
• if you are breast-feeding a baby.

Methotrexate is sometimes used to treat cancer even when patients do have one of the conditions listed above. Your doctor will decide if this treatment is right for you.

Before using methotrexate, tell your doctor if you are allergic to any drugs, or if you have:

• kidney disease;
• liver disease;
• lung disease or pneumonia;
• stomach ulcers;
• any type of infection; or
• if you are receiving radiation treatments.

FDA pregnancy category X. Methotrexate can cause birth defects in an unborn baby. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Use birth control to prevent pregnancy while you are using methotrexate, whether you are a man or a woman. Methotrexate use by either parent may cause birth defects.

Before you start taking methotrexate, your doctor may want you to have a pregnancy test to make sure you are not pregnant.

If you are a man, use a condom to keep from causing a pregnancy while you are using methotrexate. Continue using condoms for at least 90 days after your treatment ends. If you are a woman, use an effective form of birth control while you are taking methotrexate, and for at least one cycle of ovulation after your treatment ends. Do not give this medicine to a child without the advice of a doctor.

Older adults may be more likely to have side effects from this medication.

How should I take methotrexate?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

You must use the correct dose of methotrexate for your condition. The medication is sometimes taken only once per week. Some people have died after taking methotrexate every day by accident. Ask your doctor if you have any questions about your dose of methotrexate or how often to take it.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

It is important to use methotrexate regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested, and you may need an occasional liver biopsy. Do not miss any scheduled appointments.

Store methotrexate at room temperature away from moisture and heat.

What happens if I miss a dose?

Call your doctor if you miss a dose of methotrexate.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of methotrexate can be fatal.

Overdose symptoms may include pale skin, easy bruising or bleeding, unusual weakness, mouth sores, nausea, vomiting, black or bloody stools, coughing up blood or vomit that looks like coffee grounds, and urinating less than usual or not at all.

Methotrexate side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using methotrexate and call your doctor at once if you have any of these serious side effects:

• dry cough, shortness of breath;
• diarrhea, vomiting, white patches or sores inside your mouth or on your lips;
• blood in your urine or stools;
• urinating less than usual or not at all;
• fever, chills, body aches, flu symptoms;
• sore throat and headache with a severe blistering, peeling, and red skin rash;
• pale skin, easy bruising or bleeding, weakness; or
• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• nausea, vomiting, upset stomach;
• dizziness, tired feeling;
• headache;
• bleeding of your gums; or
• blurred vision.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect methotrexate?

Before taking methotrexate, tell your doctor if you are using any of the following drugs:

• azathioprine (Imuran);
• chloramphenicol (Chloromycetin);
• hydroxychloroquine (Plaquenil, Quineprox);
• retinol, tretinoin (Retin-A), isotretinoin (Accutane);
• steroids (prednisone and others);
• sulfa drugs such as Azulfidine, Bactrim, or Septra;
• phenytoin (Dilantin);
• probenecid (Benemid);
• tetracycline (Brodspec, Panmycin, Sumycin, Tetracap);
• theophylline (Elixophyllin, Slo-Bid, Theobid, Theo-Dur);
• gold treatments such as auranofin (Ridura) or aurothioglucose (Solganol);
• oral diabetes medications such as acetohexamide (Dymelor), chlorpropamide (Diabinese), glipizide (Glucotrol), glimepiride (Amaryl), or tolbutamide (Orinase);
• penicillin antibiotic such as ampicillin (Principen), amoxicillin (Amoxil, Trimox), carbenicillin (Geocillin), cloxacillin (Cloxapen), dicloxacillin (Dynapen), nafcillin (Unipen), oxacillin (Bactocill), penicillamine (Cuprimine, Depen), or Bee-Pen, Pen-Vee K, Veetids;
• salicylates such as aspirin, Disalcid, Doan’s Pills, Dolobid, Salflex, Tricosal, and others; or
• NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others.

This list is not complete and there may be other drugs that can interact with methotrexate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Baclofen is a muscle relaxer and an antispastic agent.

Baclofen is used to treat muscle symptoms caused by multiple sclerosis, including spasm, pain, and stiffness.

Baclofen may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about baclofen?

Baclofen can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of baclofen. Do not use baclofen at a time when muscle tone is needed to assure safe balance and movement for certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone.

You may have withdrawal symptoms such as seizures or hallucinations, when you stop using baclofen after using it over a long period of time. Do not stop using this medication suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

What should I discuss with my healthcare provider before taking baclofen?

Do not use this medication if you are allergic to baclofen.

Before taking baclofen, tell your doctor if you are allergic to any drugs, or if you have:

• kidney disease;
• epilepsy or other seizure disorder; or
• a history of stroke or blood clots.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether baclofen passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more sensitive to the effects of this medicine.

Do not give this medication to a child younger than 12 years old.

How should I take baclofen?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

You may take baclofen with or without food.

Call your doctor if your muscle symptoms do not improve after 2 weeks of taking this medication.

You may have withdrawal symptoms such as seizures or hallucinations, when you stop using baclofen after using it over a long period of time. Do not stop using this medication suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

Store baclofen at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Baclofen overdose symptoms may include muscle weakness, vomiting, drowsiness, dilated or pinpoint pupils, weak or shallow breathing, fainting, or coma.

What are the possible side effects of baclofen?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• seizure (convulsions);
• confusion, hallucinations; or
• an uneven heartbeat.

Less serious baclofen side effects may include:

• drowsiness, dizziness, weakness, tired feeling;
• headache;
• sleep problems (insomnia);
• nausea, constipation; or
• urinating more often than usual.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect

What other drugs will affect baclofen?

There may be other drugs that can affect baclofen. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Azathioprine lowers your body’s immune system. The immune system helps your body fight infections. The immune system can also fight or “reject” a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader.

Azathioprine is used to prevent your body from rejecting a transplanted kidney. It is also used to treat symptoms of rheumatoid arthritis.

Azathioprine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Imuran (azathioprine)?

Do not use this medication without telling your doctor if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Taking azathioprine may increase your risk of developing cancer. Talk with your doctor about your specific risk.

Azathioprine can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your kidney function may also to need to be tested. Do not miss any scheduled visits to your doctor.

Call your doctor at once if you have a fever, chills, sore throat, body aches, weakness, muscle pain, easy bruising or bleeding, mouth sores, pale stools, darkened urine, or severe nausea, vomiting, and diarrhea.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using azathioprine. You may need to stop using the medicine for a short time.

This medication can affect fertility (your ability to have children), whether you are a man or a woman. Talk with your doctor if you have concerns about this.

Do not receive a “live” vaccine while you are being treated with azathioprine and avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you.

What should I discuss with my healthcare provider before taking Imuran (azathioprine)?

Do not take this medication if you are allergic to azathioprine.

Taking azathioprine may increase your risk of developing cancer. Talk with your doctor about your specific risk.

Before taking azathioprine, tell your doctor if you are allergic to any drugs, or if you have:

• liver disease;
• any type of viral, bacterial, or fungal infection; or
• if you have recently received chemotherapy treatments with medications such as cyclophosphamide (Cytoxan), chlorambucil (Leukeran), melphalan (Alkeran).

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use azathioprine without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

This medication can affect fertility (your ability to have children), whether you are a man or a woman. Talk with your doctor if you have concerns about this.

Azathioprine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Imuran (azathioprine)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take azathioprine with a full glass of water. Take azathioprine with food to lessen stomach upset.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using azathioprine. You may need to stop using the medicine for a short time.

Azathioprine can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your kidney function may also to need to be tested. Do not miss any scheduled appointments.

Store azathioprine at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

If you take this medicine once daily and you miss a dose, take the medicine as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled time to take the medication. Do not use extra medicine to make up the missed dose.

If you take this medicine more than once daily and you miss a dose, take the medicine as soon as you remember. If it is almost time for the next dose, take both doses together, then go back to your regular dosing schedule.

Call your doctor if you have missed more than one dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, stomach pain, diarrhea, bleeding, fever, chills, and other signs of infection.

Imuran (azathioprine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• pale skin, easy bruising or bleeding, unusual weakness;
• fever, chills, sore throat, body aches, weakness, muscle pain, flu symptoms;
• severe nausea, vomiting, or diarrhea;
• severe pain in your upper stomach spreading to your back, fast heart rate;
• pain or burning with urination;
• stomach pain, loss of appetite, dark urine, clay-colored stools, and jaundice (yellowing of the skin or eyes); or
• white patches or sores inside your mouth or on your lips.

Less serious side effects may include:

• mild upset stomach, nausea, diarrhea, loss of appetite;
• hair loss; or
• skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect Imuran (azathioprine)?

Before taking azathioprine, tell your doctor if you are taking, have taken, or need to take any of the following medicines:

• allopurinol (Zyloprim);
• mercaptopurine (Purinethol);
• methotrexate (Rheumatrex, Immunex);
• a blood thinner such as warfarin (Coumadin);
• cyclosporine (Neoral, Sandimmune);
• olsalazine (Dipentum), or sulfasalazine (Azulfidine);
• sulfamethoxasole and trimethoprim (Trimpex, Proloprim, Bactrim, Septra, others); or
• an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

This list is not complete and there may be other drugs that can interact with azathioprine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Decadron, a corticosteroid drug, is used to reduce inflammation and relieve symptoms in a variety of disorders, including rheumatoid arthritis and severe cases of asthma. It may be given to people to treat primary or secondary adrenal cortex insufficiency (lack of sufficient adrenal hormone). It is also given to help treat the following disorders:

Severe allergic conditions such as drug-induced allergies
Blood disorders such as various anemias
Certain cancers (along with other drugs)
Skin diseases such as severe psoriasis
Collagen (connective tissue) diseases such as systemic lupus erythematosus
Digestive tract disease such as ulcerative colitis
High serum levels of calcium associated with cancer
Fluid retention due to nephrotic syndrome (a condition in which damage to the kidneys causes the body to lose protein in the urine)
Eye diseases such as allergic conjunctivitis
Lung diseases such as tuberculosis (along with other drugs)

Most important fact about Decadron Tablets

Decadron lowers your resistance to infections and can make them harder to treat. Decadron may also mask some of the signs of an infection, making it difficult for your doctor to diagnose the actual problem.

How should you take Decadron Tablets?

Decadron should be taken exactly as prescribed by your doctor.

If you are taking large doses, your doctor may advise you to take Decadron with meals and to take antacids between meals, to prevent a peptic ulcer from developing.

Check with your doctor before stopping Decadron abruptly. If you have been taking the drug for a long time, you may need to reduce your dose gradually over a period of days or weeks.

The lowest possible dose should always be used, and as symptoms subside, dosage should be reduced gradually.

–If you miss a dose…

Take the forgotten dose as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to your regular schedule. Never try to “catch up” by doubling the dose.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Decadron.

• More common side effects may include:
  Abdominal distention, allergic reactions, blood clots, bone fractures and degeneration, bruises, cataracts, congestive heart failure, convulsions, “cushingoid” symptoms (moon face, weight gain, high blood pressure, emotional disturbances, growth of facial hair in women), excessive hairiness, fluid and salt retention, general feeling of illness, glaucoma, headache, hiccups, high blood pressure, high blood sugar, hives, increased appetite, increased eye pressure, increased pressure in head, increased sweating, increases in amounts of insulin or hypoglycemic medications needed in diabetes, inflammation of the esophagus, inflammation of the pancreas, irregular menstruation, loss of muscle mass, low potassium levels in blood (leading to symptoms such as dry mouth, excessive thirst, weak or irregular heartbeat, and muscle pain or cramps), muscle weakness, nausea, osteoporosis, peptic ulcer, perforated small and large bowel, poor healing of wounds, protruding eyeballs, suppression of growth in children, thin skin, tiny red or purplish spots on the skin, torn tendons, vertigo, weight gain

Special information if you are pregnant or breastfeeding

The effects of Decadron during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Infants born to mothers who have taken substantial doses of corticosteroids during pregnancy should be carefully watched for adrenal problems. Corticosteroids appear in breast milk and can suppress growth in infants. If Decadron is essential to your health, your doctor may advise you to stop breastfeeding until your treatment with Decadron is finished.

Recommended dosage

ADULTS

Your doctor will tailor your individual dose to the condition being treated. Initial doses range from 0.75 milligram to 9 milligrams a day.

After the drug produces a satisfactory response, your doctor will gradually lower the dose to the minimum effective level.

Overdosage

Reports of overdose with this medication are rare. However, if you suspect an overdose, seek medical treatment immediately.

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Flexisyn is designed to alleviate the pain and inflammation associated with Arthritis, thereby effecting over time, a possible increase in a sufferers mobility and flexibility.

How Taken

Consult your healthcare provider to establish your personal dosage.

Drug Class and Mechanism

Flexisyn contains safe and natural Cox-2 inhibitors, such as Feverfew and Turmeric, and antiinflammatory herbs, such as Cat’s Claw and Licorice root. Formulated to be safe and effective, the ingredients in Flexisyn can provide relief from the joint pain and inflammation associated with rheumatoid arthritis and osteoarthritis without the negative side effects of prescription drugs.

Flexisyn treats the Stevens-Johnson syndrome, a skin disorder, caused by BEXTRA (valdecoxib), and potential heart problems associated with CELEBREX (celecoxib).

Missed Dose

If you miss a dose of Flexisyn, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Storage

Store Flexisyn at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Flexisyn out of the reach of children and away from pets.

Warnings Precautions

Seek the advice of a health care professional if you have any medical condition.

Possible Side Effects

Because Flexisyn is an all-natural nutritional supplement containing only the finest botanicals, there are no harmful side effects when taken as directed.

More Information

Flexisyn is not a pharmaceutical drug and contains none of the synthetic chemicals found in prescription medications. It is a safe alternative to prescription drugs, which can sometimes have serious side effects.

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Probenecid reduces the amount of uric acid in your body by causing more uric acid to be passed out in your urine.

Probenecid is used to treat gout and gouty arthritis. Probenecid is also used to increase the effectiveness of some antibiotics.

Probenecid may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Benemid (probenecid)?

To reduce the risk that kidney stones will form, drink at least 8 to 10 full glasses (8 ounces) of fluid every day, unless your doctor tells you not to. Take probenecid with food or an antacid to lessen stomach upset. Do not take aspirin, salsalate (Disalcid), magnesium salicylate (Magan, Doan’s), choline and magnesium salicylate (Trilisate), or other aspirin-like products unless your doctor approves. These products decrease the effects of probenecid. Taking one aspirin a day to reduce the risk of a heart attack is usually acceptable, if prescribed by your doctor.

What should I discuss with my healthcare provider before taking Benemid (probenecid)?

Before taking this medication, tell your doctor if you

• have ever had an allergic reaction to probenecid,
• have kidney disease or poorly functioning kidneys,
• have kidney stones,
• have an ulcer in your stomach,
• have blood problems, or
• are on high-dose aspirin or salicylate therapy.

You may not be able to take probenecid, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Probenecid is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take probenecid without first talking to your doctor if you are pregnant. It is not known whether probenecid will harm a nursing baby. Do not take probenecid without first talking to your doctor if you are breast-feeding a baby. Probenecid is not approved for use by children younger than 2 years of age.

How should I take Benemid (probenecid)?

Take probenecid exactly as directed by your doctor. If you do not understand the directions on your prescription bottle, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose of probenecid with a full glass of water. Also, to reduce the risk of kidney stone formation, drink at least 8 to 10 full glasses (8 ounces) of fluid every day, unless your doctor tells you not to. Take probenecid with food or with an antacid to lessen stomach upset. If nausea, vomiting, or loss of appetite is severe or persistent, consult your doctor. Store probenecid at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a probenecid overdose include nausea, vomiting, seizures, and coma. An overdose of probenecid can result in death.

Benemid (probenecid) side effects

If you experience any of the following serious side effects, stop taking probenecid and seek emergency medical attention:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
• blood in your urine or pain when you urinate; or
• a rash or hives.

Other, less serious side effects may be more likely to occur. Continue to take probenecid and talk to your doctor if you experience

• mild nausea, vomiting, or loss of appetite;
• headache or dizziness;
• sore gums;
• flushing; or
• an acute gouty arthritis attack.

Side effects other than those listed here may also occur. Talk to your doctor about any reaction that seems unusual or that is especially bothersome.

What other drugs will affect Benemid (probenecid)?

Do not take aspirin, salsalate (Disalcid), magnesium salicylate (Magan, Doan’s), choline and magnesium salicylate (Trilisate), or other aspirin-like products unless your doctor approves. These products decrease the effects of probenecid. Taking, one aspirin a day to reduce the risk of a heart attack is usually acceptable, if prescribed by your doctor.

Probenecid may increase the effects of many other drugs by preventing their removal through the kidneys. This could lead to dangerous side effects. Before taking probenecid, tell your doctor if you are taking any of the following medicines:

• acyclovir (Zovirax);
• allopurinol (Zyloprim);
• penicillamine (Cuprimine);
• clofibrate (Atromid-S);
• rifampin (Rifadin, Rimactane);
• methotrexate (Rheumatrex);
• zidovudine (Retrovir);
• acetaminophen (Tylenol, many others);
• theophylline (Slo-Bid, Theo-Dur, Elixophyllin, Slo-Phyllin, Theolair, Theochron, others);
• dapsone;
• a penicillin or cephalosporin antibiotic such as amoxicillin (Amoxil, Trimox, Augmentin, others), ampicillin (Principen, others), cephalexin (Keflex), cefuroxime (Ceftin), cefpodoxime (Vantin), cefixime (Suprax), and others;
• a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Oruvail, Orudis KT), diclofenac (Cataflam, Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), tolmetin (Tolectin), and naproxen (Aleve, Anaprox, Naprosyn);
• a sulfa-based medication such as sulfamethoxazole (Bactrim, Septra, Gantanol), sulfasalazine (Azulfidine), sulfinpyrazone (Anturane), sulfisoxazole (Gantrisin), and others;
• an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Micronase, Diabeta, Glynase), tolbutamide (Orinase), or tolazamide (Tolinase);
• a barbiturate such as phenobarbital (Luminal, Solfoton), amobarbital (Amytal), secobarbital (Seconal), and others; or
• a benzodiazepine (used to treat anxiety and panic disorders and to induce sleep) such as alprazolam (Xanax), diazepam (Valium), lorazepam (Ativan), temazepam (Restoril), chlordiazepoxide (Librium), clonazepam (Klonopin), clorazepate (Tranxene), oxazepam (Serax), estazolam (ProSom), flurazepam (Dalmane), quazepam (Doral), or triazolam (Halcion).

You may require a dosage adjustment or special monitoring during your treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with probenecid. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Benemid

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Because colchicine was developed prior to federal regulations requiring FDA review of all marketed drug products, the uses for colchicine have not been approved by the FDA. Newer drugs have been developed and FDA-approved to treat the conditions that colchicine is used to treat.

The combination of colchicine and probenecid is FDA-approved to treat affects the way the body responds to uric acid crystals, which reduces swelling and pain.

Colchicine affects the way the body responds to uric acid crystals, which reduces swelling and pain.

Colchicine is used to treat or prevent attacks of gout. It is also used to treat symptoms of Behcets syndrome (such as swelling, redness, warmth, and pain).

Colchicine is not a cure for gouty arthritis or Behcets syndrome, and it will not prevent these diseases from progressing.

Colchicine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about colchicine?

Because colchicine was developed prior to federal regulations requiring FDA review of all marketed drug products, the uses for colchicine have not been approved by the FDA. Newer drugs have been developed and FDA-approved to treat the conditions that colchicine is used to treat. You should not use this medication if you are allergic to colchicine, or if you have heart disease, kidney disease, or a severe gastrointestinal disorder.

Before taking colchicine, tell your doctor if you have a stomach ulcer, ulcerative colitis, Crohn’s disease, or intestinal bleeding or other disorder.

To treat a gout attack, for best results take colchicine at the first sign of the attack. The longer you wait to start taking the medication, the less effective it may be.

If you use this medication over a long period of time, your blood may need to be tested on a regular basis. Do not miss any scheduled appointments.

Call your doctor at once if you have a serious side effect such as severe vomiting or diarrhea, easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms, numbness, burning, pain, or tingly feeling, blood in your urine, or urinating less than usual or not at all.

What should I discuss with my healthcare provider before taking colchicine?

You should not use this medication if you are allergic to colchicine, or if you have:

• heart disease;
• kidney disease; or
• a severe gastrointestinal disorder.

Before taking colchicine, tell your doctor if you are allergic to any drugs, or if you have:

• a stomach ulcer;
• ulcerative colitis;
• Crohn’s disease; or
• intestinal bleeding or other disorder.

If you have any of these conditions, you may need a dose adjustment or special tests during to safely take colchicine.

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether colchicine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take colchicine?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

To treat a gout attack, for best results take colchicine at the first sign of the attack. The longer you wait to start taking the medication, the less effective it may be.

Colchicine is usually taken every 2 hours until you feel relief from pain or until the medication causes side effects. Follow your doctor’s instructions.

If you need to take a second course of colchicine, wait until at least 3 days have passed since the start of your last gout attack.

To prevent gout attacks, colchicine may be taken every day or several days a week. Follow your doctor’s instructions.

If you use this medication over a long period of time, your blood may need to be tested on a regular basis. Do not miss any scheduled appointments.

Store colchicine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of colchicine can be fatal.

Overdose symptoms may include diarrhea (may be bloody and severe), nausea, vomiting, stomach pain, heartburn, a burning feeling in your throat or stomach, muscle weakness, urinating less than usual, numbness or tingling, fainting, or seizure (convulsions).

Colchicine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• severe vomiting or diarrhea;
• easy bruising or bleeding, unusual weakness;
• fever, chills, body aches, flu symptoms;
• numbness, burning, pain, or tingly feeling;
• blood in your urine; or
• urinating less than usual or not at all.

Less serious side effects may include:

• mild nausea or stomach pain;
• mild diarrhea;
• muscle pain; or
• hair loss.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect colchicine?

There may be other drugs that can interact with colchicine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Colchicine

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Probalan is used in the treatment of chronic gout or gouty arthritis. These conditions are caused by too much uric acid in the blood.

How Taken

Use Probalan as directed by your doctor.

• Take Probalan tablets by mouth.
• Swallow the tablets with a drink of water.
• Take your doses at regular intervals.

Ask your health care provider any questions you may have about how to use Probalan.

Drug Class and Mechanism

Probalan works by removing the extra uric acid from the body. Probalan does not cure gout, but after you have been taking it for a few months it will help prevent gout attacks. Probalan will help prevent gout attacks only as long as you continue to take it.

Probalan is also used to prevent or treat other medical problems that may occur if too much uric acid is present in the body.

Probalan is sometimes used with certain kinds of antibiotics to make them more effective in the treatment of infections.

Missed Dose

If you miss a dose of Probalan, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Storage

Store Probalan at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Probalan out of the reach of children and away from pets.

Warnings Precautions

Do not use Probalan if:

• you are allergic to any ingredient in Probalan;
• you have blood problems or kidney stones caused by uric acid;
• the patient is a child younger than 2 years of age;
• you are taking salicylates (e.g., aspirin).

Contact your doctor or health care provider right away if any of these apply to you.
Important :

• Probalan may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Probalan. Using Probalan alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Probalan.
• Diabetes patients - Probalan may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
• Probalan may interfere with some lab tests (e.g., blood or hemoglobin urine tests, theophylline levels). Make sure your doctor and lab personnel know you are using Probalan.
• Lab tests, including tests for sugar in the urine, may be required to monitor your progress. Be sure to keep all doctor and lab appointments.
• Use of Probalan is not recommended in children younger than 2 years of age. Safety and effectiveness in this age group have not been confirmed.
• Pregnancy and breast-feeding: If you become pregnant while taking Probalan, discuss with your doctor the benefits and risks of using Probalan during pregnancy. Probalan is excreted in breast milk. If you are or will be breast-feeding while you are using Probalan, check with your doctor or pharmacist to discuss the risks to your baby.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

• dizziness; flushing; hair loss; headache; loss of appetite; nausea; sore gums; vomiting.

Seek medical attention right away if any of these severe side effects occur:

• severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; chills; dark urine; decreased or increased urination; fever; lower back, lower stomach, genital, or inner thigh pain; persistent sore throat; severe or persistent nausea, vomiting, or stomach pain; unusual bleeding or bruising; unusual tiredness or weakness; worsening gout; yellowing of the eyes or skin.

More Information

Probalan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor

Probalan

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Indomethacin is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Indomethacin works by reducing hormones that cause inflammation and pain in the body.

Indomethacin is used to treat pain or inflammation caused by many conditions such as arthritis, gout, ankylosing spondylitis, bursitis, or tendinitis.

Indomethacin may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Indocin (indomethacin)?

This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use indomethacin. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking indomethacin. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Do not drink alcohol while taking indomethacin. Alcohol can increase the risk of stomach bleeding caused by indomethacin. Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar toindomethacin (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.

What should I discuss with my healthcare provider before taking Indocin (indomethacin)?

Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Do not use this medication if you are allergic to indomethacin, or if you have a history of allergic reaction to aspirin or other NSAIDs.

Before taking indomethacin tell your doctor if you are allergic to any drugs, or if you have:

• a history of heart attack, stroke, or blood clot;
• heart disease, congestive heart failure, high blood pressure;
• a history of stomach ulcers or bleeding;
• liver or kidney disease,
• a seizure disorder such as epilepsy;
• asthma;
• polyps in your nose;
• a bleeding or blood clotting disorder; or
• if you smoke.

If you have any of these conditions, you may not be able to use indomethacin, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking indomethacin during the last 3 months of pregnancy may result in birth defects. Do not take indomethacin during pregnancy unless your doctor has told you to. Indomethacin passes into breast milk and may affect a nursing baby. Do not take indomethacin without first talking to your doctor if you are breast-feeding a baby. Do not give this medicine to a child younger than 14 years old without the advice of a doctor.

How should I take Indocin (indomethacin)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take indomethacin with food or milk to lessen stomach upset. Do not crush, chew, break, or open an extended-release capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

If you take indomethacin for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using indomethacin.

Store indomethacin at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

What happens if I miss a dose?

If you are taking indomethacin on a regular schedule, take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose.

If you are taking indomethacin as needed, take the missed dose if it is needed, then wait the recommended or prescribed amount of time before taking another dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an indomethacin overdose may include nausea, vomiting, stomach pain, drowsiness, black or bloody stools, coughing up blood, shallow breathing, fainting, or coma.

Indocin (indomethacin) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking indomethacin and seek medical attention or call your doctor at once if you have any of these serious side effects:

• chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
• black, bloody, or tarry stools;
• coughing up blood or vomit that looks like coffee grounds;
• swelling or rapid weight gain;
• urinating less than usual or not at all;
• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
• bruising, severe tingling, numbness, pain, muscle weakness.

Keep taking indomethacin and talk to your doctor if you have any of these less serious side effects:

• upset stomach, mild heartburn, diarrhea, constipation;
• bloating, gas;
• dizziness, nervousness, headache;
• skin rash, itching;
• blurred vision; or
• ringing in your ears.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Indocin (indomethacin)?

Before taking indomethacin, tell your doctor if you are taking any of the following drugs:

• aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac (Voltaren), etodolac (Lodine), flurbiprofen (Ansaid), ibuprofen (Advil, Motrin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others;
• a blood thinner such as warfarin (Coumadin);
• cyclosporine (Gengraf, Neoral, Sandimmune);
• diflunisal (Dolobid);
• digoxin (digitalis, Lanoxin);
• diuretics (water pills) such as furosemide (Lasix);
• lithium (Eskalith, Lithobid);
• methotrexate (Rheumatrex, Trexall);
• probenecid (Benemid);
• steroids (prednisone and others); or
• a beta-blocker such as atenolol (Tenormin), bisoprolol (Zebeta), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), timolol (Blocadren), and others.

If you are using any of these drugs, you may not be able to use indomethacin or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect indomethacin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Indocin

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