Amiloride is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.
Amiloride is used to treat or prevent hypokalemia (low potassium levels in the blood).
Amiloride may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about Midamor (Amiloride / Furosemide)?
Do not use this medication if you have kidney disease, urination problems, or high levels of potassium in your blood. Do not use potassium supplements or other diuretics while you are taking amiloride.
Before using this medication, tell your doctor if you have heart or liver disease, or a breathing disorder.
Avoid drinking alcohol, which can increase some of the side effects of amiloride.
Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.
Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking amiloride.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor’s instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
What should I discuss with my doctor before taking Midamor (Amiloride / Furosemide)?
Do not use this medication if you have:
kidney disease or are unable to urinate;
high potassium levels (hyperkalemia); or
if you are taking potassium supplements, or another potassium-sparing diuretic such Moduretic, spironolactone (Aldactone, Aldactazide), or triamterene (Dyrenium, Dyazide, Maxzide).
If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before using amiloride, tell your doctor if you have:
diabetes;
heart disease;
cirrhosis or other liver disease;
a breathing disorder; or
if you are using another diuretic.
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether amiloride passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take Midamor (Amiloride / Furosemide)?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from this medication.
Take each dose with a full glass of water. Take amiloride with food.
To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.
Amiloride can interfere with the results of a glucose tolerance test. Stop using this medication for at least 3 days before you have this test. Tell any doctor who treats you that you are using amiloride.
Store this medication at room temperature away from heat, light, and moisture. Do not allow the tablets to freeze.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.
Overdose symptoms may include dizziness, thirst, feeling light-headed, slow heartbeat, or fainting.
Midamor (Amiloride / Furosemide) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
headache;
mild nausea, loss of appetite;
gas, stomach pain; or
skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Midamor (Amiloride / Furosemide)?
Before taking this medication, tell your doctor if you are using any of the following drugs:
cyclosporine (Neoral, Sandimmune, Gengraf);
tacrolimus (Prograf);
lithium;
an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others; or
indomethacin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), naproxen (Aleve, Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others.
This list is not complete and there may be other drugs that can interact with amiloride. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Florinef is used for treating adrenocortical insufficiency in Addison disease and for treating salt-losing adrenogenital syndrome.
How to use
Use Florinef as directed by your doctor.
Take Florinef by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
Do not suddenly stop taking Florinef. You may have an increased risk of side effects. If you need to stop Florinef or add a new medicine, your doctor will gradually lower your dose.
Ask your health care provider any questions you may have about how to use Florinef.
Drug Class and Mechanism
Florinef is a corticosteroid. It works by causing the kidneys to retain sodium and acting as a replacement for cortisone when the body does not produce enough.
Missed Dose
If you miss a dose of Florinef and are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Storage
Store Florinef at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Florinef out of the reach of children and away from pets.
Warnings/Precautions
Do not use Florinef if:
you are allergic to any ingredient in Florinef;
you have a systemic fungal infection;
you are scheduled to have a smallpox vaccination.
Contact your doctor or health care provider right away if any of these apply to you.
Important:
Florinef may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Florinef with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Florinef may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does. Tell your doctor right away if you are exposed to anyone who has these infections.
Carry an ID card at all times that says you take Florinef.
Tell your doctor or dentist that you take Florinef before you receive any medical or dental care, emergency care, or surgery.
Long-term use may cause cataracts, glaucoma, and eye infections. Contact your doctor right away if you develop any unusual changes in your vision.
Florinef may cause an increase in blood pressure, salt and water retention, and calcium and potassium loss. Talk with your doctor to see if you need to decrease the amount of salt in your diet or take a calcium or vitamin D supplement.
Do not receive a live vaccine (e.g., measles, mumps) while you are taking Florinef. Talk with your doctor before you receive any vaccine.
Diabetes patients – Florinef may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
Lab tests, including blood electrolytes, blood calcium levels, blood pressure, and vision tests may be performed while you use Florinef. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Caution is advised when using Florinef in children; they may be more sensitive to its effects.
Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Florinef while you are pregnant. Florinef is found in breast milk. If you are or will be breast-feeding while using Florinef, check with your doctor. Discuss any possible risks to your baby.
Possible Side Effects
Check with your doctor if any of these most common side effects persist or become bothersome:
Seek medical attention right away if any of these severe side effects occur:
severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in menstrual periods; chest pain; eye pain or increased pressure in the eye; fever, chills, or sore throat; joint or bone pain; mood or mental changes (e.g., depression); muscle pain or weakness; seizures; severe or persistent headache; severe or persistent nausea or vomiting; stomach pain or bloating; swelling of feet or legs; trouble sleeping; unusual weight gain or loss; vision changes; vomiting material that looks like coffee grounds.
More Information
Florinef is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
Prazosin is in a class of drugs called alpha-adrenergic blockers. Prazosin causes the blood vessels (veins and arteries) to relax and expand, which allows blood to pass more easily through them.
Prazosin is used to treat hypertension (high blood pressure).
Prazosin may be used for purposes other than those listed in this medication guide.
What is the most important information I should know about Minipress (Prazosin)?
To avoid falling, take the first dose at bedtime. Prazosin may cause dizziness. It is a good idea to take every dose at bedtime, if possible.
Use caution when you stand or sit up from a lying position, especially if you wake up during the night. Dizziness may occur when changing positions.
Do not stop taking this drug suddenly even if you feel better. Stopping suddenly could cause your blood pressure to increase.
Who should not take Minipress (Prazosin)?
Before taking this medication, tell your doctor if you have any type of kidney or liver disease. You may need a dosage adjustment or special monitoring during therapy with prazosin. Prazosin is in the FDA pregnancy category C. This means that it is not known whether prazosin will harm an unborn baby. Do not take prazosin without first talking to your doctor if you are pregnant. Prazosin passes into breast milk and may affect a nursing baby. Do not take prazosin without first talking to your doctor if you are breast-feeding a baby.
How should I take Minipress (Prazosin)?
Take prazosin exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass of water. To avoid falling, take the first dose at bedtime. Prazosin may cause dizziness. It is a good idea to take every dose at bedtime, if possible.
Use caution when you stand or sit up from a lying position, especially if you wake up during the night. Dizziness may occur when changing positions.
Do not stop taking this drug suddenly even if you feel better. Stopping suddenly could cause your blood pressure to increase. Store this medication at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose of this medication. A double dose could cause your blood pressure to become severely low.
If you miss doses for several days in a row, call your doctor before taking any additional doses. You may need to restart treatment with a lower dose.
What happens if I overdose?
Seek emergency medical attention.
Symptoms of a prazosin overdose include weakness, dizziness, and fainting; a weak, fast pulse; cold, clammy skin; and possibly loss of consciousness or coma.
Minipress (Prazosin) side effects
If you experience any of the following serious side effects, stop taking prazosin and seek emergency medical attention or contact your doctor immediately:
an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
an increased heartbeat;
shortness of breath or chest pain; or
a rash.
Other, less serious side effects may be more likely to occur. Continue to take prazosin and talk to your doctor if you experience
vivid dreams;
dizziness or drowsiness;
weakness, fatigue, or ill feeling;
nausea, vomiting, diarrhea, constipation, abdominal pain, or decreased appetite;
fluid retention or slight weight gain;
joint or muscle aches;
headache, irritability, or depression;
increased urination;
decreased sex drive; or
numbness or tingling in your hands, feet, arms, or legs.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Minipress (Prazosin) Dosing Information
Usual Adult Dose for Congestive Heart Failure:
Initial dose: 1 mg orally 2-3 times a day.
Maintenance dose: 6-15 mg daily given in divided doses.
Usual Adult Dose for Hypertension:
Initial dose: 1 mg orally 2-3 times a day.
Maintenance dose: 6-15 mg daily given in divided doses.
Usual Adult Dose for Benign Prostatic Hyperplasia:
Initial dose: 1 mg orally 2-3 times a day.
Maintenance dose: 6-15 mg daily given in divided doses.
Usual Pediatric Dose for not applicable:
Greater than 1 year:
Initial dose: 5 mcg/kg orally.
Maintenance dose: Increase dose gradually up to 25 mcg/kg orally every 6 hours. Maximum daily dose is 15 mg or 0.4 mg/kg/day.
What other drugs will affect Minipress (Prazosin)?
Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal supplements, during treatment with prazosin.
Roxithromycin is used to treat various infections caused by bacteria.
For example:
Acute pharyngitis (sore throat and discomfort when swallowing);
Tonsillitis;
Sinusitis;
Acute bronchitis (infection of the bronchi causing coughing);
Pneumonia (lung infection characterised by fever, malaise, headache);
Skin and soft tissue infections;
Non gonococcal urethritis;
Impetigo (bacterial infection causing sores on the skin).
How to use
Use Roxithromycin as directed by your doctor.
Take Roxithromycin by mouth with food.
If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water.
Ask your health care provider any questions you may have about how to use Roxithromycin.
Drug Class and Mechanism
Roxithromycin is used to treat serious infections. It kills or slows the growth of sensitive bacteria.
Missed Dose
If you miss a dose of Roxithromycin and are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Storage
Store Roxithromycin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Roxithromycin out of the reach of children and away from pets.
Warnings/Precautions
Do not use Roxithromycin if:
you are allergic to any ingredient in Roxithromycin.
Contact your doctor or health care provider right away if any of these apply to you.
Important :
Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
Be sure to use Roxithromycin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
Long-term or repeated use of Roxithromycin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Roxithromycin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Roxithromycin while you are pregnant. Erythromycin is found in breast milk. If you are or will be breast-feeding while you use Roxithromycin, check with your doctor. Discuss any possible risks to your baby.
Possible Side Effects
Check with your doctor if any of these most common side effects persist or become bothersome:
diarrhea; loss of appetite; nausea; stomach pain; vomiting.
Seek medical attention right away if any of these severe side effects occur:
severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; hearing changes; irregular heartbeat; red, swollen, or blistered skin; severe diarrhea; severe stomach pain or cramps; yellowing of skin or eyes.
More Information
Roxithromycin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
Terramycin is a type of antibiotic called a tetracycline. It is used to treat infections with bacteria.
How to use
Use Terramycin as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Terramycin by mouth on an empty stomach at least 1 hour before or 2 hours after eating.
Take Terramycin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Terramycin.
If you also take antacids containing aluminum, calcium, or magnesium; preparations containing bismuth, iron, zinc, or sodium bicarbonate; or calcium rich foods (eg, milk, dairy products, calcium-enriched juices), do not take them within 2 to 3 hours before or after taking Terramycin . Check with your doctor if you have questions.
To clear up your infection completely, take Terramycin for the full course of treatment. Keep taking it even if you feel better in a few days.
Drug Class and Mechanism
Terramycin is a tetracycline antibiotic. It works by slowing the growth of sensitive bacteria by interfering with the production of proteins needed by the bacteria to grow. Slowing the bacteria’s growth allows the body’s defense mechanisms to destroy them.
Missed Dose
If you miss a dose of Terramycin , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Storage
Store Terramycin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Terramycin out of the reach of children and away from pets.
Warnings/Precautions
Do NOT use Terramycin if:
you are allergic to any ingredient in Terramycin or other tetracycline antibiotics (eg, doxycycline)
you are taking acitretin or methoxyflurane
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Terramycin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have diarrhea, a stomach infection, or kidney problems
Some MEDICINES MAY INTERACT with Terramycin . Tell your health care provider if you are taking any other medicines, especially any of the following:
Acitretin or isotretinoin because side effects, such as increased pressure in the fluid surrounding the brain, may occur
Digoxin, methotrexate, methoxyflurane, or oral anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Terramycin Atovaquone, lithium, oral contraceptives (birth control pills), or penicillins (eg, amoxicillin) because their effectiveness may be decreased by Terramycin
Possible Side Effects
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Black hairy tongue; blurred vision; bulky loose stools; diarrhea; difficulty swallowing; fever; headache; hives; hoarseness; indigestion; inflammation or redness of tongue; joint pain; loss of appetite; mouth sores; nausea; rash; sensitivity to sunlight; sore throat; stomach pain; swelling and itching of the rectum.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); infection (fever, chills, sore throat); itching; nausea; severe skin reaction to the sun; vaginal irritation or discharge; vomiting.
More Information
If you have any questions about Terramycin , please talk with your doctor, pharmacist, or other health care provider.
Terramycin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
Amoxicillin is an antibiotic in the penicillin group of drugs. It fights bacteria in your body.
Amoxicillin is used to treat many different types of infections caused by bacteria, such as ear infections, bladder infections, pneumonia, gonorrhea, and E. coli or salmonella infection. Amoxicillin is also sometimes used together with another antibiotic called clarithromycin (Biaxin) to treat stomach ulcers caused by Helicobacter pylori infection. This combination is sometimes used with a stomach acid reducer called lansoprazole (Prevacid).
Amoxicillin may also be used for other purposes not listed in this medication guide.
Important information about Brand Amoxil (Amoxicillin)
Do not use this medication if you are allergic to amoxicillin or to any other penicillin antibiotic, such as ampicillin (Omnipen, Principen), carbenicillin (Geocillin), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.
Before using amoxicillin, tell your doctor if you are allergic to cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others. Also tell your doctor if you have asthma, liver or kidney disease, a bleeding or blood clotting disorder, mononucleosis (also called “mono”), or any type of allergy.
Amoxicillin can make birth control pills less effective, which may result in pregnancy. Before taking amoxicillin, tell your doctor if you use birth control pills. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Amoxicillin will not treat a viral infection such as the common cold or flu. Do not give this medication to another person, even if they have the same symptoms you do.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.
Before taking Brand Amoxil (Amoxicillin)
Do not use this medication if you are allergic to amoxicillin or to any other penicillin antibiotic, such as:
Before using amoxicillin, tell your doctor if you are allergic to any drugs (especially cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others), or if you have:
asthma;
liver disease;
kidney disease;
a bleeding or blood clotting disorder;
mononucleosis (also called “mono”);
a history of diarrhea caused by taking antibiotics; or
a history of any type of allergy.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take amoxicillin.
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Amoxicillin can make birth control pills less effective, which may result in pregnancy. Before taking amoxicillin, tell your doctor if you use birth control pills. Amoxicillin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
The amoxicillin chewable tablet may contain phenylalanine. Talk to your doctor before using this form of amoxicillin if you have phenylketonuria (PKU).
How should I take Brand Amoxil (Amoxicillin)?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
If you are taking amoxicillin with clarithromycin and/or lansoprazole to treat stomach ulcer, use all of your medications as directed. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.
You may take amoxicillin with or without food.
Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
You may place the liquid directly on the tongue, or you may mix it with water, milk, baby formula, fruit juice, or ginger ale. Drink all of the mixture right away. Do not save any for later use.
The chewable tablet should be chewed before you swallow it.
Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. Breaking or opening the pill may cause too much of the drug to be released at one time.
To be sure this medication is helping your condition, your blood may need to be tested. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.
If you are being treated for gonorrhea, your doctor may also have you tested for syphilis, another sexually transmitted disease.
Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Amoxicillin will not treat a viral infection such as the common cold or flu. Do not give amoxicillin to another person, even if they have the same symptoms you do.
This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using amoxicillin.
Store amoxicillin at room temperature away from moisture, heat, and light. You may store liquid amoxicillin in a refrigerator but do not allow it to freeze. Throw away any liquid amoxicillin that is not used within 14 days after it was mixed at the pharmacy.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.
Overdose symptoms may include confusion, behavior changes, a severe skin rash, urinating less than usual, or seizure (black-out or convulsions).
Brand Amoxil (Amoxicillin) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
diarrhea that is watery or bloody;
fever, chills, body aches, flu symptoms;
easy bruising or bleeding, unusual weakness;
urinating less than usual or not at all;
agitation, confusion, unusual thoughts or behavior; or
seizure (black-out or convulsions).
Less serious side effects are more likely to occur, such as:
nausea, vomiting, stomach pain;
vaginal itching or discharge;
headache;
swollen, black, or “hairy” tongue; or
thrush (white patches inside your mouth or throat).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Brand Amoxil (Amoxicillin)?
Before taking amoxicillin, tell your doctor if you are using any of the following drugs:
methotrexate (Rheumatrex, Trexall);
probenecid (Benemid);
a sulfa drug (such as Bactrim or Septra);
an antibiotic such as azithromycin (Zithromax), clarithromycin (Biaxin), erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin), telithromycin (Ketek), or troleandomycin (Tao); or
a tetracycline antibiotic such as demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).
This list is not complete and there may be other drugs that can interact with amoxicillin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Ampicillin is an antibiotic in the penicillin group of drugs. It fights bacteria in your body.
Ampicillin is used to treat many different types of infections caused by bacteria, such as ear infections, bladder infections, pneumonia, gonorrhea, and E. coli or salmonella infection.
Ampicillin may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about Ampicillin?
Do not use this medication if you are allergic to ampicillin or to any other penicillin antibiotic, such as amoxicillin (Amoxil), carbenicillin (Geocillin), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.
Before using ampicillin, tell your doctor if you are allergic to cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others, or if you have asthma, kidney disease, a bleeding or blood clotting disorder, mononucleosis (also called “mono”), or a history of any type of allergy.
Ampicillin can make birth control pills less effective, which may result in pregnancy. Before taking ampicillin, tell your doctor if you use birth control pills. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Ampicillin will not treat a viral infection such as the common cold or flu. Do not give this medication to another person, even if they have the same symptoms you do.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.
What should I discuss with my healthcare provider before taking Ampicillin?
Do not use this medication if you are allergic to ampicillin or to any other penicillin antibiotic, such as:
Before using ampicillin, tell your doctor if you are allergic to any drugs (especially cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others), or if you have:
asthma;
kidney disease;
a bleeding or blood clotting disorder;
mononucleosis (also called “mono”);
a history of diarrhea caused by taking antibiotics; or
a history of any type of allergy.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take ampicillin.
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Ampicillin can make birth control pills less effective, which may result in pregnancy. Before taking ampicillin, tell your doctor if you use birth control pills. Ampicillin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take Ampicillin?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Take the medicine with a full glass of water. Ampicillin should be taken on an empty stomach, at least 1 hour before or 2 hours after eating a meal.
To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.
If you are being treated for gonorrhea, your doctor may also have you tested for syphilis, another sexually transmitted disease.
Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Ampicillin will not treat a viral infection such as the common cold or flu. Do not give ampicillin to another person, even if they have the same symptoms you do.
This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using ampicillin.
Store ampicillin at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.
Overdose symptoms may include confusion, behavior changes, a severe skin rash, urinating less than usual, or seizure (black-out or convulsions).
Ampicillin side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
diarrhea that is watery or bloody;
fever, chills, body aches, flu symptoms;
easy bruising or bleeding, unusual weakness;
urinating less than usual or not at all;
agitation, confusion, unusual thoughts or behavior; or
seizure (black-out or convulsions).
Less serious side effects may include
nausea, vomiting, stomach pain;
vaginal itching or discharge;
headache;
swollen, black, or “hairy” tongue; or
thrush (white patches or inside your mouth or throat).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Ampicillin Dosing Information
Usual Adult Dose for Bacterial Endocarditis Prophylaxis:
Low to moderate risk: 2 g IV or IM 30 minutes before procedure.
High risk: Ampicillin 2 g plus gentamicin 1.5 mg/kg IV or IM 30 minutes before procedure. Follow with ampicillin 1 g IV or IM, or amoxicillin 1 g orally, 6 hours after initial dose.
Usual Adult Dose for Bronchitis:
Bacterial exacerbations of chronic bronchitis:
250 to 500 mg orally every 6 hours for 5 to 10 days, depending on the nature and severity of the infection.
Usual Adult Dose for Endocarditis:
Enterococcal:
Ampicillin 2 g IV every 4 hours plus gentamicin 1 mg/kg IV every 8 hours for 4 to 6 weeks.
Usual Adult Dose for Gastroenteritis:
250 to 500 mg orally every 6 hours.
Usual Adult Dose for Intraabdominal Infection:
1 to 2 g IV every 4 to 6 hours in combination with other antibiotics, depending on the nature and severity of the infection.
Duration: 10-14 days.
Usual Adult Dose for Leptospirosis:
Moderate to severe: 0.5 to 1 g intravenously every 6 hours.
Mild: 500 to 750 mg orally every 6 hours.
Usual Adult Dose for Meningitis:
IV:
200 mg/kg/day (up to 12 g/day) IV in equally divided doses every 4 hours, in combination with other parenteral antibiotics.
Intrathecal or intraventricular:
10 to 50 mg/day in addition to IV antibiotics.
Usual Adult Dose for Peritonitis:
CAPD-associated peritonitis: 250 to 500 mg orally twice daily and/or 100 to 125 mg/L exchange intraperitoneally, with or without other antibiotics depending on the nature and severity of the infection.
Secondary: 1 to 2 g IV every 4 to 6 hours in combination with other antibiotics, depending on the nature and severity of the infection.
Duration: 10 to 14 days.
Usual Adult Dose for Pneumonia:
Beta-lactamase negative, penicillin-susceptible: 1 to 2 g IV every 4 to 6 hours, in combination with other antibiotic(s) depending on the nature and severity of the infection.
Usual Adult Dose for Prevention of Perinatal Group B Streptococcal Disease:
As an alternative to penicillin G: 2 g IV as a loading dose, followed by 1 g every 4 hours until delivery.
Usual Adult Dose for Pyelonephritis:
500 mg to 2 g IV or IM every 4 to 6 hours with or without other antibiotics, depending on the nature and severity of the infection.
Duration: 2 to 3 weeks.
Usual Adult Dose for Septicemia:
1 to 2 g IV every 3 to 4 hours, in combination with other antibiotics.
Usual Adult Dose for Shigellosis:
500 mg orally every 6 hours for 5 days
Usual Adult Dose for Skin or Soft Tissue Infection:
250 to 500 mg orally every 6 hours or 1 to 2 g IV every 4 to 6 hours, depending on the nature and severity of the infection.
Usual Adult Dose for Surgical Prophylaxis:
Liver transplant: Ampicillin 1 g plus cefotaxime 1 g IV at induction, then every 6 hours for 48 hours after closure.
Usual Adult Dose for Typhoid Fever:
Severe, fully susceptible: 25 mg/kg IV or IM every 6 hours for 10 to 14 days.
Carrier state: 1.5 g orally or IV with probenecid 500 mg every 6 hours for 6 weeks.
Fluoroquinolones or amoxicillin are considered the drugs of choice.
Usual Adult Dose for Otitis Media:
500 mg orally or 1 to 2 g IV or IM every 6 hours, depending on the nature and severity of the infection.
Usual Adult Dose for Pharyngitis:
500 mg orally or 1 to 2 g IV or IM every 6 hours, depending on the nature and severity of the infection.
Usual Adult Dose for Sinusitis:
500 mg orally or 1 to 2 g IV or IM every 6 hours, depending on the nature and severity of the infection.
Usual Adult Dose for Upper Respiratory Tract Infection:
500 mg orally or 1 to 2 g IV or IM every 6 hours, depending on the nature and severity of the infection.
Usual Adult Dose for Urinary Tract Infection:
Mild, uncomplicated: 250 to 500 mg orally every 6 hours
Severe, complicated: 500 mg to 2 g IV every 4 to 6 hours with or without other antibiotics, depending on the nature and severity of the infection.
Usual Pediatric Dose for Bacterial Endocarditis Prophylaxis:
Low to moderate risk: 50 mg/kg IV or IM 30 minutes before procedure.
High risk: 50 mg/kg plus gentamicin 1.5 mg/kg, both intramuscularly or IV 30 minutes before procedure. Follow with ampicillin 25 mg/kg IV or IM, or amoxicillin 25 mg/kg orally, 6 hours after initial dose.
Usual Pediatric Dose for Meningitis:
Neonates:
< 7 days, birthweight < 2000 g: 50 mg/kg IV every 12 hours.
< 7 days, birthweight > 2000 g: 50 mg/kg IV every 8 hours.
> 7 days, birthweight < 1200 g: 50 mg/kg IV every 12 hours.
> 7 days, birthweight 1200 to 2000 g: 50 mg/kg IV every 8 hours.
> 7 days, birthweight > 2000 g: 50 mg/kg IV every 6 hours.
Infants and children:
50 to 100 mg/kg IV every 6 hours. Maximum dose 12 g/day.
Ampicillin should be given in combination with another antibiotic, depending on the nature of the infection.
Usual Pediatric Dose for Skin or Soft Tissue Infection:
IV: 6.25 to 12.5 mg/kg every 6 hours (maximum 12 g/day).
Oral: 6.25 to 12.5 mg/kg every 6 hours (maximum 2 to 3 g/day).
Usual Pediatric Dose for Upper Respiratory Tract Infection:
IV: 6.25 to 12.5 mg/kg every 6 hours (maximum 12 g/day).
Oral: 6.25 to 12.5 mg/kg every 6 hours (maximum 2 to 3 g/day).
Usual Pediatric Dose for Surgical Prophylaxis:
Liver transplant: Ampicillin 50 mg/kg plus cefotaxime 50 mg/kg at induction and every 6 hours for 48 hours after closure.
Usual Pediatric Dose for not applicable:
< 7 days, birthweight < 2000 g: 25 to 50 mg/kg IV or IM every 12 hours.
< 7 days, birthweight > 2000 g: 25 to 50 mg/kg IV or IM every 8 hours.
> 7 days, birthweight< 1200 g: 25 to 50 mg/kg IV or IM every 12 hours.
> 7 days, birthweight 1200 to 2000 g: 25 to 50 mg/kg IV or IM every 8 hours.
> 7 days, birthweight > 2000 g: 25 to 50 mg/kg IV or IM every 6 hours.
>1 month:
Mild to moderate infections:
Parenteral: 25 to 50 mg/kg IV or IM every 6 hours (maximum 12 g/day).
Oral: 12.5 to 25 mg/kg every 6 hours (maximum 2 to 4 g/day).
Severe infections: 50 to 100 mg/kg IV every 6 hours (maximum 12 g/day).
What other drugs will affect Ampicillin?
Before taking ampicillin, tell your doctor if you are using any of the following drugs:
allopurinol (Zyloprim);
methotrexate (Rheumatrex, Trexall);
probenecid (Benemid);
a sulfa drug (such as Bactrim or Septra); or
a tetracycline antibiotic such as demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).
This list is not complete and there may be other drugs that can interact with ampicillin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Treating severe acne. It may also be used for other conditions as determined by your doctor.
Cleocin T Gel is a topical lincomycin antibiotic. It works by killing sensitive bacteria that cause acne and reducing the amount of free fatty acids that irritate the skin surface.
Do NOT use Cleocin T Gel if:
you are allergic to any ingredient in Cleocin T Gel or to lincomycin
you have Crohn disease, antibiotic-associated colitis, or ulcerative colitis
Contact your doctor or health care provider right away if any of these apply to you.
Before using Cleocin T Gel:
Some medical conditions may interact with Cleocin T Gel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have a gastrointestinal (bowel) disease or diarrhea
Some MEDICINES MAY INTERACT with Cleocin T Gel. Tell your health care provider if you are taking any other medicines, especially any of the following:
Nondepolarizing muscle relaxants (eg, vecuronium) or succinylcholine because their actions and the risk of their side effects may be increased by Cleocin T Gel
Erythromycin because it may decrease Cleocin T Gel’s effectiveness
This may not be a complete list of all interactions that may occur. Ask your health care provider if Cleocin T Gel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Cleocin T Gel:
Use Cleocin T Gel as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Cleocin T Gel is for topical use on the skin only.
Clean and dry the affected area. Cover the affected and surrounding area with a thin film of medicine.
Cleocin T Gel works best if it is used at the same time each day.
Continue to use Cleocin T Gel even if your condition improves. Do not miss any doses.
If you miss a dose of Cleocin T Gel, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Cleocin T Gel.
Important safety information:
Cleocin T Gel may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.
Several weeks may pass before you see improvement in your acne. Continue using Cleocin T Gel for the full time recommended by your doctor.
Be sure to use Cleocin T Gel for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
Do not get Cleocin T Gel in your eyes or on the inside of your nose or mouth. If you accidentally get the medicine in your eye, immediately flush with a large amount of cool tap water.
If severe diarrhea, stomach pain or cramping, or bloody stools develop during treatment or within several months after treatment with Cleocin T Gel, check with your doctor or pharmacist right away. Do not treat it without first checking with your doctor.
Talk with your doctor before you use any other medicines or cleansers on your skin.
Cleocin T Gel should not be used in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cleocin T Gel while you are pregnant. It is not known if Cleocin T Gel is found in breast milk. Do not breast-feed while taking Cleocin T Gel.
Possible side effects of Cleocin T Gel:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Dryness; itching; oiliness or oily skin.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood or mucus in stools; bloody or severe diarrhea; stomach cramps or pain; swelling, redness, burning, or peeling of your skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Cleocin T Gel may be harmful if swallowed.
Proper storage of Cleocin T Gel:
Store Cleocin T Gel at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Protect from freezing. Keep Cleocin T Gel out of the reach of children and away from pets.
Aciclovir Capsules is used for treating chickenpox (varicella) or shingles (herpes zoster) and treating or suppressing genital herpes infections. It may also be used for other conditions as determined by your doctor.
How Taken
Use Aciclovir as directed by your doctor.
Take Aciclovir by mouth with or without food.
Drinking extra fluids while you are taking Aciclovir is recommended.
Start therapy with Aciclovir at the earliest sign or symptom of shingles or genital herpes (pain, burning, blisters).
If treating an acute outbreak, continue using Aciclovir for the full course of treatment even if you feel better in a few days.
For suppressive therapy, Aciclovir works best if it is taken at the same times each day.
Ask your health care provider any questions you may have about how to use Aciclovir.
Drug Class and Mechanism
Aciclovir is an antiviral. It works by stopping viral replication. However, Aciclovir does not eliminate the virus, is not a cure, and does not prevent transmission to others.
Missed Dose
If you miss a dose of Aciclovir and are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Storage
Store Aciclovir between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Aciclovir out of the reach of children and away from pets.
Warnings/Precautions
Do not use Aciclovir if:
you are allergic to any ingredient in Aciclovir;
if you are pregnant, planning to become pregnant, or are breast-feeding;
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement;
if you have allergies to medicines, foods, or other substances;
if you have kidney problems or a weakened immune system.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Aciclovir Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have kidney problems or a weakened immune system
Some MEDICINES MAY INTERACT with Aciclovir Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:
Medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because the risk of kidney side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidney
Possible Side Effects
Check with your doctor if any of these most common side effects persist or become bothersome:
diarrhea; general body discomfort; headache; nausea/vomiting.
Seek medical attention right away if any of these severe side effects occur:
severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); aggressive behavior; blood in the urine; confusion; decreased consciousness; decreased urination; hallucinations; lower back pain; mental or mood changes; red, swollen, blistered, or peeling skin; seizures; unusual bruising or bleeding.
More Information
If you have any questions about Aciclovir Capsules, please talk with your doctor, pharmacist, or other health care provider.
Aciclovir Capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
Glimepiride and pioglitazone is a combination of two oral diabetes medicines that help control blood sugar levels.
Glimepiride and pioglitazone is for people with type 2 diabetes who do not use daily insulin injections. Glimepiride and pioglitazone is sometimes given with other diabetes medications when greater blood sugar control is needed.
This medication is not for treating type 1 diabetes.
Glimepiride and pioglitazone may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about Duetact (Glimepiride / Pioglitazone)?
You should not use this medication if you are allergic to glimepiride or pioglitazone, if you have severe heart failure, or if you are in a state of diabetic ketoacidosis.
Before taking glimepiride and pioglitazone, tell your doctor if you have congestive heart failure or heart disease, a history of heart attack or stroke, liver disease, or kidney disease.
Taking certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with glimepiride and pioglitazone. Know the signs of low blood sugar (hypoglycemia) and how to recognize them, including hunger, headache, confusion, irritability, drowsiness, weakness, dizziness, tremors, sweating, fast heartbeat, seizure (convulsions), fainting, or coma (severe hypoglycemia can be fatal). Always keep a source of sugar available in case you have symptoms of low blood sugar.
What should I discuss with my health care provider before taking Duetact (Glimepiride / Pioglitazone)?
You should not use this medication if you are allergic to glimepiride (Amaryl, Avandaryl) or pioglitazone (Actos), or if you have:
severe heart failure; or
if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before you take glimepiride and pioglitazone, tell your doctor if you have:
congestive heart failure or heart disease;
a history of heart attack or stroke; or
liver or kidney disease.
Taking certain oral diabetes medication may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with glimepiride and pioglitazone. Some women using glimepiride and pioglitazone have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control. FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether this medication passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take Duetact (Glimepiride / Pioglitazone)?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results from this medication.
Take glimepiride and pioglitazone with your first meal of the day.
Glimepiride and pioglitazone is only part of a complete program of treatment that also includes diet, exercise, and weight control. It is important to use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your liver function may also need to be tested, and you may need regular eye exams. Do not miss any scheduled visits to your doctor.
Your medication needs may change if you become sick or injured, if you have a serious infection, or if you have any type of surgery. Your doctor may want you to stop taking glimepiride and pioglitazone for a short time if any of these situations affect you.
Take care not to let your blood sugar get too low, causing hypoglycemia. You may have hypoglycemia if you skip a meal, exercise too long, drink alcohol, or are under stress.
Know the signs of low blood sugar (hypoglycemia) and how to recognize them:
hunger, headache, confusion, irritability;
drowsiness, weakness, dizziness, tremors;
sweating, fast heartbeat;
seizure (convulsions); or
fainting, coma (severe hypoglycemia can be fatal).
Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.
If your blood sugar gets too high (hyperglycemia), you may feel very thirsty or hungry. You may also urinate more than usual. Call your doctor right away if you have any symptoms of hyperglycemia. Store glimepiride and pioglitazone at room temperature, protected from moisture, heat, and light.
What happens if I miss a dose?
Take the missed dose as soon as you remember (be sure to take the medicine with food). If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine. A glimepiride overdose can cause life-threatening hypoglycemia.
Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).
Duetact (Glimepiride / Pioglitazone) side effects
Stop using glimepiride and pioglitazone and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
swelling in your feet, rapid weight gain, feeling short of breath (even with mild exertion);
pale skin, easy bruising or bleeding;
pain or burning when you urinate; or
dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
nausea, vomiting, weakness, loss of appetite, feeling restless or irritable, confusion, hallucinations, muscle pain or weakness, and/or seizure.
Less serious side effects may include:
sneezing, stuffy nose, cough, sore throat, or other cold symptoms;
gradual weight gain;
mild nausea, diarrhea;
headache, dizziness, blurred vision;
tooth problems; or
mild itching or skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Duetact (Glimepiride / Pioglitazone)?
Before taking glimepiride and pioglitazone, tell your doctor if you are taking:
delavirdine (Rescriptor);
gemfibrozil (Lopid);
nicardipine (Cardene) or nifedipine (Adalat, Procardia); or
rifampin (Rifadin, Rimactane, Rifater); or
fluconazole (Diflucan), ketoconazole (Nizoral).
Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any of the following:
albuterol (Proventil, Ventolin);
clonidine (Catapres);
reserpine;
guanethidine (Ismelin); or
beta-blockers such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.
You may be more likely to have hyperglycemia (high blood sugar) if you are taking glimepiride and pioglitazone with other drugs that raise blood sugar. Drugs that can raise blood sugar include:
isoniazid;
diuretics (water pills);
steroids (prednisone and others);
phenothiazines (Compazine and others);
thyroid medicine (Synthroid and others);
birth control pills and other hormones;
seizure medicines (Dilantin and others); and
diet pills or medicines to treat asthma, colds or allergies.
You may be more likely to have hypoglycemia (low blood sugar) if you are taking glimepiride and pioglitazone with other drugs that lower blood sugar. Drugs that can lower blood sugar include:
probenecid (Benemid);
some nonsteroidal anti-inflammatory drugs (NSAIDs);
aspirin or other salicylates (including Pepto-Bismol);
sulfa drugs (Bactrim, Gantanol, Septra, and others); and
a monoamine oxidase inhibitor (MAOI).
This list is not complete and there may be other drugs that can interact with glimepiride and pioglitazone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
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